CAJ | 학술논문

目的探讨2型糖尿病(T2DM)家系成员血浆肿瘤坏死因子α(TNF-α)水平与胰岛素敏感性的关系. 方法采用放射免疫法检测了32例家族性T2DM患者、37例家族性T2DM患者的非DM一级亲属,40例正常人的血浆TNF-α水平. 结果家族性T2DM患者血浆TNF-α为(1.19±0.21)μg/L, 明显高于正常对照组(1.00±0.18)μg/L(P<0.05).家族性T2DM患者的非DM一级亲属血浆TNF-α为(1.01±0.28)μg/L,与正常对照组比较,差异无显著性.逐步回归分析显示,血浆TNF-α水平与胰岛素敏感性指数(ISI)呈负相关,TNF-α参与了ISI的变异,血浆总胆固醇(TC)、体重指数(BMI)、TNF-α对ISI总的影响程度为39%. 结论循环TNF-α可能参与了家族性T2DM患者胰岛素抵抗的形成.
목적탐토2형당뇨병(T2DM)가계성원혈장종류배사인자α(TNF-α)수평여이도소민감성적관계. 방법채용방사면역법검측료32례가족성T2DM환자、37례가족성T2DM환자적비DM일급친속,40례정상인적혈장TNF-α수평. 결과가족성T2DM환자혈장TNF-α위(1.19±0.21)μg/L, 명현고우정상대조조(1.00±0.18)μg/L(P<0.05).가족성T2DM환자적비DM일급친속혈장TNF-α위(1.01±0.28)μg/L,여정상대조조비교,차이무현저성.축보회귀분석현시,혈장TNF-α수평여이도소민감성지수(ISI)정부상관,TNF-α삼여료ISI적변이,혈장총담고순(TC)、체중지수(BMI)、TNF-α대ISI총적영향정도위39%. 결론순배TNF-α가능삼여료가족성T2DM환자이도소저항적형성.
Objective To study plasma tumor necrosis factor α(TNF α) level and its relationship with insulin resistance in familial type 2 DM. Methods Plasma TNF α were determined by RIA in 32 familial type 2 DM patients, their 37 non diabetic first degree relatives and 40 healthy control subjects. Results Plasma TNF α was significantly higher in familial type 2 DM patients[(1.19±0.21)μg/L] than in healthy control subjects[(1.00±0.18)μg/L]( P <0.05), with no significant difference found between the non diabetic first degree relatives [(1.01±0.28)μg/L] and healthy control ( P >0.05). Regression analysis indicated that TNF α was inversely related to ISI and was a significantly independent contributor to variations in ISI. 39% of the variance in ISI was explained by TC, body mass index(BMI)and TNF α. Conclusion The finding of an association between high plasma levels of TNF α and insulin resistance suggests that TNF α may be involved in the pathophysiology of insulin resistance in familial type 2 DM patients.