CAJ | 학술논문

[目的]研究Livin蛋白在原发性支气管肺癌中的表达及其临床意义.[方法]应用免疫组织化学SP法检测52例手术切除的肺癌石蜡标本及7例正常肺组织中的Livin蛋白表达情况.[结果](1)肺癌患者肺组织中Livin蛋白表达的阳性率为48.1％,正常肺组织呈阴性表达；(2)男性肺癌患者Livin蛋白的表达阳性率为59.26％,女性为36.00％,两者相比差异有统计学意义(P＜0.05)；(3)支气管肺癌的病理类型、组织分化程度、临床分期对Livin蛋白表达阳性率的影响无统计学差异(P＞0.05).而有淋巴结转移的肺癌患者Livin蛋白表达阳性率(57.89％)高于无淋巴结转移的患者(36.37％,P＜0.05)；(4)吸烟指数≥400的肺癌患者Livin蛋白表达阳性率53.57％,吸烟指数＜400的患者为33.33％,两者相比差异有统计学意义(P＜0.05).[结论]Livin蛋白的高表达在支气管肺癌的发生发展过程中起重要作用,Livin蛋白的表达与肺癌的病理类型、组织的分化程度、临床分期无关,与有无淋巴结转移、吸烟指数密切相关.
[목적]연구Livin단백재원발성지기관폐암중적표체급기림상의의.[방법]응용면역조직화학SP법검측52례수술절제적폐암석사표본급7례정상폐조직중적Livin단백표체정황.[결과](1)폐암환자폐조직중Livin단백표체적양성솔위48.1％,정상폐조직정음성표체；(2)남성폐암환자Livin단백적표체양성솔위59.26％,녀성위36.00％,량자상비차이유통계학의의(P＜0.05)；(3)지기관폐암적병리류형、조직분화정도、림상분기대Livin단백표체양성솔적영향무통계학차이(P＞0.05).이유림파결전이적폐암환자Livin단백표체양성솔(57.89％)고우무림파결전이적환자(36.37％,P＜0.05)；(4)흡연지수≥400적폐암환자Livin단백표체양성솔53.57％,흡연지수＜400적환자위33.33％,량자상비차이유통계학의의(P＜0.05).[결론]Livin단백적고표체재지기관폐암적발생발전과정중기중요작용,Livin단백적표체여폐암적병리류형、조직적분화정도、림상분기무관,여유무림파결전이、흡연지수밀절상관.
[Objective]To study the protein expression level and clinical significance of Livin gene in primary lung cancer.[Methods] The protein expression of Livin gene in paraffin specimens of 52 cases of lung cancer and 7 specimens of normal lung tissues were detected by SP immunohistochemistry.[Results] ( 1 )The positive rate of Livin protein expression in lung cancer specimens was 48.1％,but the normal lung tissues were negative staining.(2) The positive rate of Livin protein expression in male lung cancer specimens (59.26％ )was higher than that in female lung tissues(36.00％,P ＜ 0.05 ).(3)Livin protein expression in lung cancer had no obvious relationship with the pathologic type,grade,and clinical stage.The positive rate of Livin protein expression in specimens with lymph node metastasis(57.89％ )was higher than in tissues without lymph node metastasis (36.37％,P ＜ 0.05 ).(4)The positive rate of expression of Livin protein in patients whose smoking index≥400 and in patients that ＜400was53.57％ and 33.33％,respectively,the differences were significant(P ＜0.05).[Conclusions]Livin protein expression in lung cancer has no obvious relationship with the pathologic type,grade,and clinical stage.It is closely related to lymph node metastasis and smoking index.