中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2012年
13期
90-92
,共3页
栾翰林%何洹%施冲%刘晓艳%孙梅
欒翰林%何洹%施遲%劉曉豔%孫梅
란한림%하원%시충%류효염%손매
右美托咪啶%血流动力学%幕上病灶术后%不良反应
右美託咪啶%血流動力學%幕上病竈術後%不良反應
우미탁미정%혈류동역학%막상병조술후%불량반응
Dexmedetomidine%Hemodynamic%Supratentorial mass lesion postoperation%Adverse reaction
目的 观察右美托咪啶应用于幕上病灶切除术后镇静作用的临床效果.方法 选择幕上病灶切除术后患者40例(均在麻醉恢复室),年龄18 ～60岁,随机分为两组,每组20例.试验组:10 min静脉泵注右美托咪啶0.8 μg/kg后,以0.6 μg·kg-1·h-1维持40 min;对照组:10 min静脉泵注生理盐水10 ml后,20ml生理盐水静脉泵注40 min.记录患者血压、心率、呼吸等变化,观察给药后患者镇静作用以及不良反应的发生情况.结果 试验组给入右美托咪啶后HR、MAP均低于基础值,对比对照组差异具有统计学意义(P＜0.05)；RR各个时间点则无明显变化；试验组均达到Ramsay镇静分级Ⅳ级状态.结论 右美托咪啶(负荷量0.8μg/kg,维持0.6μg·kg-1·h-1)应用于幕上病灶切除术后患者取得了满意的镇静效果.
目的 觀察右美託咪啶應用于幕上病竈切除術後鎮靜作用的臨床效果.方法 選擇幕上病竈切除術後患者40例(均在痳醉恢複室),年齡18 ～60歲,隨機分為兩組,每組20例.試驗組:10 min靜脈泵註右美託咪啶0.8 μg/kg後,以0.6 μg·kg-1·h-1維持40 min;對照組:10 min靜脈泵註生理鹽水10 ml後,20ml生理鹽水靜脈泵註40 min.記錄患者血壓、心率、呼吸等變化,觀察給藥後患者鎮靜作用以及不良反應的髮生情況.結果 試驗組給入右美託咪啶後HR、MAP均低于基礎值,對比對照組差異具有統計學意義(P＜0.05)；RR各箇時間點則無明顯變化；試驗組均達到Ramsay鎮靜分級Ⅳ級狀態.結論 右美託咪啶(負荷量0.8μg/kg,維持0.6μg·kg-1·h-1)應用于幕上病竈切除術後患者取得瞭滿意的鎮靜效果.
목적 관찰우미탁미정응용우막상병조절제술후진정작용적림상효과.방법 선택막상병조절제술후환자40례(균재마취회복실),년령18 ～60세,수궤분위량조,매조20례.시험조:10 min정맥빙주우미탁미정0.8 μg/kg후,이0.6 μg·kg-1·h-1유지40 min;대조조:10 min정맥빙주생리염수10 ml후,20ml생리염수정맥빙주40 min.기록환자혈압、심솔、호흡등변화,관찰급약후환자진정작용이급불량반응적발생정황.결과 시험조급입우미탁미정후HR、MAP균저우기출치,대비대조조차이구유통계학의의(P＜0.05)；RR각개시간점칙무명현변화；시험조균체도Ramsay진정분급Ⅳ급상태.결론 우미탁미정(부하량0.8μg/kg,유지0.6μg·kg-1·h-1)응용우막상병조절제술후환자취득료만의적진정효과.
Objective To investigate the clinical sedation efficacy of dexmedetomidine for the patients undergoing supratentorial mass lesion postoperation.Methods 40 cases in the post-anesthesia care unit.ASA physical status I and Ⅱ.Patients underwent elective supratentorial mass lesion surgery who were randomly divided into two groups.Group A:Dexmedetomidine (an initial dose of 0.8 μg/kg for 10 min,followed by a continuous infusion of 0.6 μg · kg-1 · h-1 ).Group B:placebo saline was administered.MAP,HR,SpO2,RR,Ramesay assessment of sedation and adverse reaction were recored.Results The hemodynamic status of Group A was more influenced.Adverse reaction was significantly lesser in Group A.The experimental group at different time points on blood pressure,heart rate were lower than the control group,obvious difference in the two groups( P ＜0.05).Group A had small influence of MAP and RR.The degree of sedation which 0.6 μg · kg -1 · h -1 produced was quite suitable the clinical practice.Conclusions Dexmedetomidine ( an initial dose of 0.8 μg/kg for 10 min,followed by a continuous infusion of 0.6 μg · kg-1 · h-1 )has good sedative for the patients undergoing supratentorial mass lesion postoperation.
