CAJ | 학술논문

树突状细胞(DC)是介导T细胞免疫应答的有力启动细胞,白血病来源DC同样具有抗原提呈及摄取能力.用肿瘤抗原冲击DC在体外、体内能够有效地触发T细胞免疫应答,成为肿瘤特异性细胞毒性T细胞.介绍了DC的生物学特性、肿瘤免疫、白血病细胞的肿瘤逃逸机制以及DC在白血病免疫治疗中的研究进展情况.
수돌상세포(DC)시개도T세포면역응답적유력계동세포,백혈병래원DC동양구유항원제정급섭취능력.용종류항원충격DC재체외、체내능구유효지촉발T세포면역응답,성위종류특이성세포독성T세포.개소료DC적생물학특성、종류면역、백혈병세포적종류도일궤제이급DC재백혈병면역치료중적연구진전정황.
Dendritic cells are the most powerful cells to induce T cell immune reaction. DC derived from leukemia also possess the ability of the antigen processing and presentation. DC pulsed with tumor antigen can effectively initiate T cell immune reaction and induce T cell to cytotoxic T lymphocytes in vitro and in vivo. In this text, we introduce the advanced development of the biological character of DC, tumor immunology, the mechanism of tumor cell escaping immune surveillance and DC in leukemia immunotherapy.