中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
5期
417-420
,共4页
韩莉%汤浩%卢青%江海腾%姚志剑
韓莉%湯浩%盧青%江海騰%姚誌劍
한리%탕호%로청%강해등%요지검
男性%抑郁症%注意控制%皮层-边缘系统%脑磁图
男性%抑鬱癥%註意控製%皮層-邊緣繫統%腦磁圖
남성%억욱증%주의공제%피층-변연계통%뇌자도
Male%Depression%Attentional control%Cortical-limbic pathways%Magnetoencephalography
目的 检测高同质性男性抑郁症患者注意控制相关脑区功能动态变化的情况.方法 利用脑磁图检测12例单相复发男性抑郁症患者,以及12名年龄、受教育年限近似匹配的男性健康对照者完成Stroop字色干扰测试任务时脑功能的改变.结果 将0～1000ms时间段按先后顺序每100ms显示男性患者激活异常脑区,其中激活显著减弱的脑区有:左中央后回(t=3.10)、右额上回(t=2.16)、左额中回(t=2.64)、左顶叶(t=2.89)、右颞中回(t=1.92)、右颞上回(t=2.84)、右脑岛(t＝3.03)、右楔前叶(t=2.98)、双侧额中回(t=3.64,t=2.25)、右中央后回(t=2.20)、右扣带回(t=4.04)、双侧楔前叶(t=2.79,t＝1.87)；激活显著增高的脑区有:左尾状核体(t=2.21)、左脑岛(t=2.31)、左丘脑枕(t=2.36)、左尾状核体(t=1.91)、左丘脑枕(t=2.56)、左颞中回(t＝1.89)、左中央前回(t=2.02).设P＜0.05时,差异具有统计学意义.结论 男性单相复发抑郁症患者完成Stroop字色干扰测试任务时参与注意控制加工的脑区功能较正常人存在异常,加工时程中呈现皮层减弱、边缘系统增强的功能分离状态.
目的 檢測高同質性男性抑鬱癥患者註意控製相關腦區功能動態變化的情況.方法 利用腦磁圖檢測12例單相複髮男性抑鬱癥患者,以及12名年齡、受教育年限近似匹配的男性健康對照者完成Stroop字色榦擾測試任務時腦功能的改變.結果 將0～1000ms時間段按先後順序每100ms顯示男性患者激活異常腦區,其中激活顯著減弱的腦區有:左中央後迴(t=3.10)、右額上迴(t=2.16)、左額中迴(t=2.64)、左頂葉(t=2.89)、右顳中迴(t=1.92)、右顳上迴(t=2.84)、右腦島(t＝3.03)、右楔前葉(t=2.98)、雙側額中迴(t=3.64,t=2.25)、右中央後迴(t=2.20)、右釦帶迴(t=4.04)、雙側楔前葉(t=2.79,t＝1.87)；激活顯著增高的腦區有:左尾狀覈體(t=2.21)、左腦島(t=2.31)、左丘腦枕(t=2.36)、左尾狀覈體(t=1.91)、左丘腦枕(t=2.56)、左顳中迴(t＝1.89)、左中央前迴(t=2.02).設P＜0.05時,差異具有統計學意義.結論 男性單相複髮抑鬱癥患者完成Stroop字色榦擾測試任務時參與註意控製加工的腦區功能較正常人存在異常,加工時程中呈現皮層減弱、邊緣繫統增彊的功能分離狀態.
목적 검측고동질성남성억욱증환자주의공제상관뇌구공능동태변화적정황.방법 이용뇌자도검측12례단상복발남성억욱증환자,이급12명년령、수교육년한근사필배적남성건강대조자완성Stroop자색간우측시임무시뇌공능적개변.결과 장0～1000ms시간단안선후순서매100ms현시남성환자격활이상뇌구,기중격활현저감약적뇌구유:좌중앙후회(t=3.10)、우액상회(t=2.16)、좌액중회(t=2.64)、좌정협(t=2.89)、우섭중회(t=1.92)、우섭상회(t=2.84)、우뇌도(t＝3.03)、우설전협(t=2.98)、쌍측액중회(t=3.64,t=2.25)、우중앙후회(t=2.20)、우구대회(t=4.04)、쌍측설전협(t=2.79,t＝1.87)；격활현저증고적뇌구유:좌미상핵체(t=2.21)、좌뇌도(t=2.31)、좌구뇌침(t=2.36)、좌미상핵체(t=1.91)、좌구뇌침(t=2.56)、좌섭중회(t＝1.89)、좌중앙전회(t=2.02).설P＜0.05시,차이구유통계학의의.결론 남성단상복발억욱증환자완성Stroop자색간우측시임무시삼여주의공제가공적뇌구공능교정상인존재이상,가공시정중정현피층감약、변연계통증강적공능분리상태.
Objective To study information transmission circumstances within the neural circuits related to the attentional controls of the mate depression patients.Methods Twelve unipolar depression patients and twelve age- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the variation of brain inhibitory function by Magnetoencephalography scanning.Results Compared with the healthy controls,the abnormally activities in depressed patients during in chronological order were separately as follow:decreased activation in the left postcentral gyrus ( t =3.10 ),the right superior frontal gyrus ( t =2.16 ),the left middle frontal gyrus (t=2.64),the left parietal lobe (t=2.89),the right middle temporal grus( t=1.92),the right superior temporal gyrus(t=2.84),the right insula(t=3.03),the right precuneus(t=2.98),the bilateral middle frontal gyros ( t =3.64,t =2.25 ),the right postcentral gyrus ( t =2.20),the right cingulate gyrus ( t =4.04 ),the bilateral precuneus ( t =2.79,t =1.87 ) ;increased activation in the left caudate body ( t =1.91 ),the left pulvinar ( t =2.56),the left middle temporal gyrus( t =1.89),the left precentral gyrus( t =2.02) (P ＜ 0.05,uncorrected).Conclusion The abnormal activation in the brain regions related with attentional control processing is detected in the male recurrent unipolar recurrent major depression,performances of limbic system increased and.cortex declined more in the recurrent depressed.
