CAJ | 학술논문

肿瘤干细胞是肿瘤发生、发展、转移及复发的根源.虽然机体有严密的免疫监视机制,但肿瘤干细胞可以通过改变表面抗原、表达免疫逃逸相关基因及逃逸相关的表面标志物,或诱导具有免疫抑制能力的细胞或细胞因子的分泌等多种机制有效地逃避免疫系统的监视.此外,肿瘤干细胞免疫逃逸与其微环境中的各种间质细胞和细胞外因子的作用也密切相关.这些机制的研究有助于加深对肿瘤干细胞的认识,为肿瘤的预防和治疗提供新的理论指导.
종류간세포시종류발생、발전、전이급복발적근원.수연궤체유엄밀적면역감시궤제,단종류간세포가이통과개변표면항원、표체면역도일상관기인급도일상관적표면표지물,혹유도구유면역억제능력적세포혹세포인자적분비등다충궤제유효지도피면역계통적감시.차외,종류간세포면역도일여기미배경중적각충간질세포화세포외인자적작용야밀절상관.저사궤제적연구유조우가심대종류간세포적인식,위종류적예방화치료제공신적이론지도.
Tumor stem cells are the root of tumor development, metastasis and recurrence. Although the body has various immunosurveillance mechanisms, tumor stem cells can evade immunosurveillance effectively via changing the surface antigens, expressing immune escape associated genes and surface markers, or inducing immune suppressive cells and cytokines secretion. In addition, the role of various mesenchymal cells and cytokines in tumor microenvironment are also closely related to tumor stem cells immune escape. Studies of these mechanisms will contributed to a better understanding of tumor stem cells. It provided a new theoretical instruction for tumor prevention and treatment. Our review focused on the advancements of the mechanisms of tumor stem cells escaping the attacking of immune system.