CAJ | 학술논문

支气管哮喘(简称哮喘)是多种细胞及其组分参与的慢性非特异性炎症性疾病,气道反复炎症损伤与修复造成的气道重塑是哮喘主要的病理生理学特征,预防气道重塑是哮喘干预治疗的重要潜在靶点,是改善哮喘预后的重要手段.Rho通过激活下游效应物Rho相关卷曲螺旋形成蛋白激酶(Rho associated coiled coil fotruing protein kinase,ROCK)作用于气道平滑肌细胞及调节细胞因子和炎性因子等的产生,在哮喘气道重塑的形成与发展中起关键的作用,ROCK抑制剂能有效抑制哮喘动物模型的气道炎症和气道重塑作用.
지기관효천(간칭효천)시다충세포급기조분삼여적만성비특이성염증성질병,기도반복염증손상여수복조성적기도중소시효천주요적병리생이학특정,예방기도중소시효천간예치료적중요잠재파점,시개선효천예후적중요수단.Rho통과격활하유효응물Rho상관권곡라선형성단백격매(Rho associated coiled coil fotruing protein kinase,ROCK)작용우기도평활기세포급조절세포인자화염성인자등적산생,재효천기도중소적형성여발전중기관건적작용,ROCK억제제능유효억제효천동물모형적기도염증화기도중소작용.
Bronchial asthma (asthma) is a chronic non-specific inflammatory disease. The main pathophysiological feature of asthma is airway remodeling which is a result of airways' repeated injury and plerosis. Prevention of airway remodeling, which is thought to be an important potential target for asthmatic intervention treatment, is also a significant measure to improve the prognosis of asthma. Rho protein can affect the airway smooth muscle contraction through Rho kinase and regulate cytokines and inflammatory factors which play an important role in the pathogenesis of asthma. Both of them are involved in the formation of airway remodeling. Rho kinase inhibitors can effectively inhibit airway inflammation and airway remodeling in asthmatic animals.