CAJ | 학술논문

外周血大部分T细胞膜表面抗原受体分子(TCR)由α/β多肽链构成,α/βTCR特异性识别抗原多肽与MHC分子复合物.分析克隆性增生TCR BV CDR3的基因谱型特征,可以了解机体T细胞增殖与功能状况,从而有助于T细胞相关疾病的诊断和治疗,通过直接移植特异性T细胞来治疗相关疾病,也能发展以特异性TCR基因为基础的转基因技术来治疗相应疾病.此文主要就TCR β链特点及其在感染性疾病的诊断与治疗上的应用作了阐述.
외주혈대부분T세포막표면항원수체분자(TCR)유α/β다태련구성,α/βTCR특이성식별항원다태여MHC분자복합물.분석극륭성증생TCR BV CDR3적기인보형특정,가이료해궤체T세포증식여공능상황,종이유조우T세포상관질병적진단화치료,통과직접이식특이성T세포래치료상관질병,야능발전이특이성TCR기인위기출적전기인기술래치료상응질병.차문주요취TCR β련특점급기재감염성질병적진단여치료상적응용작료천술.
Most of the peripheral blood T lymphocyte antigen receptor(TCR)molecules on the surface membrane organized with α and β petide chain, and α/β TCR identifies specific antigen peptide with MHC molecules complex. Analysis of clonal proliferation of TCR BV CDR3 gene patterns characteristic of the body can understand the statue of T cell proliferation and function situation, contributing to diagnosis and treatment for the T cell-related diseases. The specific T cell can be transplanted directly for treatment of related diseases, and the specific TCR gene-based transgenic technology can be used to treat corresponding diseases as well. In this article, the characteristics of TCR β chain and its application in diagnosis and treatment for infectious disease are discussed.