中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
9期
722-725
,共4页
沈琳%高海青%由倍安%邱洁
瀋琳%高海青%由倍安%邱潔
침림%고해청%유배안%구길
冠状动脉疾病%小动脉硬化%冠状血管造影术
冠狀動脈疾病%小動脈硬化%冠狀血管造影術
관상동맥질병%소동맥경화%관상혈관조영술
Coronary artery disease%Arteriolosclerosis%Coronary angiography
目的 观察老年冠状动脉粥样硬化患者和冠心病患者大动脉弹性指数(C1)和小动脉弹性指数(C2)的变化，探讨C1、C2与老年冠状动脉粥样硬化狭窄病变Gensini积分的相关性。 方法 入选160例行选择性冠状动脉造影的老年患者，分为3组：冠状动脉正常组（正常组）、冠状动脉粥样硬化组（硬化组）和冠心病组。应用桡动脉舒张期脉搏波形分析仪测定入选者的动脉弹性，得到C1和C2；冠状动脉造影后对所有入选者的冠状动脉狭窄病变程度应用Gensini积分法进行定量评定；分别对硬化组和冠心病组的C1、C2与Gensini积分间的相关性进行直线相关分析。 结果 硬化组的C2低于正常组（P＜0.01），冠心病组的C2低于硬化组(P＜0.05)，3组间的C1比较，差异无统计学意义；硬化组和冠心病组患者Gensini积分分别为（5.4±2.6）分与（51.3±32.1）分，两组比较差异有统计学意义（t= 10.574，P＜0.01）;冠状动脉狭窄病变Gensini积分均与C2呈负相关，与C1无相关性。 结论在老年冠状动脉粥样硬化这一亚临床阶段，C2已开始下降，并随着冠状动脉粥样硬化病变程度的加重而降低，测定C2有助于老年冠状动脉粥样硬化患者的早期发现。
目的 觀察老年冠狀動脈粥樣硬化患者和冠心病患者大動脈彈性指數(C1)和小動脈彈性指數(C2)的變化，探討C1、C2與老年冠狀動脈粥樣硬化狹窄病變Gensini積分的相關性。 方法 入選160例行選擇性冠狀動脈造影的老年患者，分為3組：冠狀動脈正常組（正常組）、冠狀動脈粥樣硬化組（硬化組）和冠心病組。應用橈動脈舒張期脈搏波形分析儀測定入選者的動脈彈性，得到C1和C2；冠狀動脈造影後對所有入選者的冠狀動脈狹窄病變程度應用Gensini積分法進行定量評定；分彆對硬化組和冠心病組的C1、C2與Gensini積分間的相關性進行直線相關分析。 結果 硬化組的C2低于正常組（P＜0.01），冠心病組的C2低于硬化組(P＜0.05)，3組間的C1比較，差異無統計學意義；硬化組和冠心病組患者Gensini積分分彆為（5.4±2.6）分與（51.3±32.1）分，兩組比較差異有統計學意義（t= 10.574，P＜0.01）;冠狀動脈狹窄病變Gensini積分均與C2呈負相關，與C1無相關性。 結論在老年冠狀動脈粥樣硬化這一亞臨床階段，C2已開始下降，併隨著冠狀動脈粥樣硬化病變程度的加重而降低，測定C2有助于老年冠狀動脈粥樣硬化患者的早期髮現。
목적 관찰노년관상동맥죽양경화환자화관심병환자대동맥탄성지수(C1)화소동맥탄성지수(C2)적변화，탐토C1、C2여노년관상동맥죽양경화협착병변Gensini적분적상관성。 방법 입선160례행선택성관상동맥조영적노년환자，분위3조：관상동맥정상조（정상조）、관상동맥죽양경화조（경화조）화관심병조。응용뇨동맥서장기맥박파형분석의측정입선자적동맥탄성，득도C1화C2；관상동맥조영후대소유입선자적관상동맥협착병변정도응용Gensini적분법진행정량평정；분별대경화조화관심병조적C1、C2여Gensini적분간적상관성진행직선상관분석。 결과 경화조적C2저우정상조（P＜0.01），관심병조적C2저우경화조(P＜0.05)，3조간적C1비교，차이무통계학의의；경화조화관심병조환자Gensini적분분별위（5.4±2.6）분여（51.3±32.1）분，량조비교차이유통계학의의（t= 10.574，P＜0.01）;관상동맥협착병변Gensini적분균여C2정부상관，여C1무상관성。 결론재노년관상동맥죽양경화저일아림상계단，C2이개시하강，병수착관상동맥죽양경화병변정도적가중이강저，측정C2유조우노년관상동맥죽양경화환자적조기발현。
Objective To investigate the changes of capacitive arterial compliance(C1) and oscillatory arterial compliance (C2) in elderly patients with the coronary atherosclerosis and the coronary heart disease (CHD)and to study the association between Gensini Score and C1 or C2.Methods Elderly subjects (160 cases) were divided into three groups according to the results of selective coronary angiography: the normal,the coronary atherosclerosis and the CHD group. C1 and C2 were measured using a DO-2020 cardiovascular profiling instrument. The stenosis severity of coronary artery diseases was assessed using a scoring system called Gensini score. Bivariate analyses were performed to study the association between Gensini Score of coronary artery and each of C1 and C2.Results C2 in the coronary atherosclerosis group was significantly lower than that in the normal group, and higher than in CHD group. C1 had no statistically difference among the three groups. Gensini integral in the coronary atherosclerosis versus the CHD groups were ( 5.4+2.6) vs.( 51.3+ 32.1), respectively (t= 10.574, P＜0.01). Gensini Score in the coronary atherosclerosis group had no relation with C1, and was negtively correlated with C2. Conclusions C2 is decreased in the early stages of the coronary artery atherosclerosis in elderly patients, and may help the identification of early coronary atherosclerosis.
