CAJ | 학술논문

目的探讨黄韧带骨化(ossification ofligamentum flavum,OLF)的临床流行病学特征,评估OLF在普通人群中的发病率、形态和分布特点.进行相关OLF流行病学研究的meta分析.方法对1736名中国南方人进行脊柱的临床影像学研究,分别进行MRI T2加权的矢状位成像,OLF定义为一椎管后方的低信号区,并在CT上证实.根据OLF累及的节段分为单一型、连续型和非连续型;根据矢状位T2加权像上OLF的形态学特征分为三角形、圆形和鸟喙形三种.检索Ovid Medline、PubMed、Embase和中国生物文献数据库(1980年1月至2010年1月),搜集全部有关OLF的流行病学研究.结果共有66例志愿者发现有脊柱OLF,其中女52例,男14例.根据该研究新的分型,单一型45例(68.2%),连续型11例(16.7%),非连续型10例(15.2%);形态学上,92个OLF中,17个(18.5%)为三角形,75个(81.5%)为圆形骨化物.纳入研究的OLF流行病学研究共有4篇.结论 OLF在中国南方人群中的患病率约为3.8%(66/1736),发生率与年龄和性别相关;31.8%的多节段OLF和15.2%的非连续型OLF均提示全脊柱MR检查的必要性.
목적 탐토황인대골화(ossification ofligamentum flavum,OLF)적림상류행병학특정,평고OLF재보통인군중적발병솔、형태화분포특점.진행상관OLF류행병학연구적meta분석.방법 대1736명중국남방인진행척주적림상영상학연구,분별진행MRI T2가권적시상위성상,OLF정의위일추관후방적저신호구,병재CT상증실.근거OLF루급적절단분위단일형、련속형화비련속형;근거시상위T2가권상상OLF적형태학특정분위삼각형、원형화조훼형삼충.검색Ovid Medline、PubMed、Embase화중국생물문헌수거고(1980년1월지2010년1월),수집전부유관OLF적류행병학연구.결과 공유66례지원자발현유척주OLF,기중녀52례,남14례.근거해연구신적분형,단일형45례(68.2%),련속형11례(16.7%),비련속형10례(15.2%);형태학상,92개OLF중,17개(18.5%)위삼각형,75개(81.5%)위원형골화물.납입연구적OLF류행병학연구공유4편.결론 OLF재중국남방인군중적환병솔약위3.8%(66/1736),발생솔여년령화성별상관;31.8%적다절단OLF화15.2%적비련속형OLF균제시전척주MR검사적필요성.
Objective To study the clinical epidemiology of ossification of ligamentum flavum(OLF)and evaluate its characteristics of prevalence,morphology,and distribution in a common population.Some factors associated with its occurrence were analyzed by meta-analysis.Methods A total of 1736 southern Chinese volunteers were recruited by open invitation.T2 weighted MRI sequences of whole spine in all participants were obtained.OLF was identified as an area of low signal intensity located in the posterior part of the spinal canal,and subsequently confirmed by CT scan.The distribution of OLF was classified into three types:isolated type,continuous type and non-continuous type.The morphology of the lesion was classified into triangular,round and beak shapes based on the pattern of ossification on T2 weighted sagittal MRIs.Literatures about OLF were searched in Ovid Medline,PubMed,Embase and Chinese BioMedical Literature Database from January 1980 to January 2010.Results OLF was identified in 66 volunteers including 52 females and 14 males.According to the new classification of the study,there were 45 cases of single type (68.2%),11 cases of continuous type(16.7%)and 10 cases of non-continuous type(15.2%).In 92 OLF,there were 17 triangular shape(18.5%)and 75 rounded shape according to morphological classification.A literature review showed that there were only 4 reports related to the prevalence of OLF.Conclusion This study demonstrated that morbidity rate of OLF is about 3.8% in southern Chinese population.The incidence is related to age and gender.It is necessary to perform whole spine MRI examination to detect the multiple level and noncontinous type.