中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2009年
1期
47-51
,共5页
蒋杰%王奇峰%肖泽芬%王绿化%陈东福%冯勤富%周宗枚%吕纪马%欧广飞%梁军%殷蔚伯
蔣傑%王奇峰%肖澤芬%王綠化%陳東福%馮勤富%週宗枚%呂紀馬%歐廣飛%樑軍%慇蔚伯
장걸%왕기봉%초택분%왕녹화%진동복%풍근부%주종매%려기마%구엄비%량군%은위백
食管肿瘤/三维适形放射疗法%生存分析%预后
食管腫瘤/三維適形放射療法%生存分析%預後
식관종류/삼유괄형방사요법%생존분석%예후
Esophageal neoplasms/three-dimensional con_formal radiotherapy%Survival analysis%Prognosis
目的 分析和评估三维适形放疗技术对食管癌患者的疗效及影响预后的因素.方法 回顾分析3年间采用三维适形放疗的132例未手术食管癌患者的临床资料,分析其生存率、局部控制率和影响预后的因素.结果 全组1、3、4年局部控制率分别为65.4.5%、52.9%、52.9%.全组1、3、4年生存率分别为50.7%、29.9%、25.7%,中位生存期为13个月.Ⅰ-Ⅲ期食管癌1、2、3、4年生存率分别为56.7%、36.7%、33.3%、30.3%,Ⅳ期1、2年生存率分别为35.2%、14.7%,没有3年生存,中位生存时间分别为15个月和9个月(x2=8.17,P=0.004).肿瘤长度≤8.0 cm、分期均为Ⅰ-Ⅲ期、疗前没有穿孔征象、接受全程三维适形放疗的1、3、4年生存率分别为67.6%、46.3%、40.6%,中位生存时间为27个月.单因素分析显示疗前进食情况、穿孔征象、病变长度、TNM分期、疗后食管x线片评价是影响预后的因素.多因素分析显示穿孔征象、肿瘤长度是独它预后因素.结论 三维适形放疗能明显提高部分食管癌患者的局部控制率和生存率.疗前是否有穿孔征象、肿瘤长度是影响预后的独立因素.
目的 分析和評估三維適形放療技術對食管癌患者的療效及影響預後的因素.方法 迴顧分析3年間採用三維適形放療的132例未手術食管癌患者的臨床資料,分析其生存率、跼部控製率和影響預後的因素.結果 全組1、3、4年跼部控製率分彆為65.4.5%、52.9%、52.9%.全組1、3、4年生存率分彆為50.7%、29.9%、25.7%,中位生存期為13箇月.Ⅰ-Ⅲ期食管癌1、2、3、4年生存率分彆為56.7%、36.7%、33.3%、30.3%,Ⅳ期1、2年生存率分彆為35.2%、14.7%,沒有3年生存,中位生存時間分彆為15箇月和9箇月(x2=8.17,P=0.004).腫瘤長度≤8.0 cm、分期均為Ⅰ-Ⅲ期、療前沒有穿孔徵象、接受全程三維適形放療的1、3、4年生存率分彆為67.6%、46.3%、40.6%,中位生存時間為27箇月.單因素分析顯示療前進食情況、穿孔徵象、病變長度、TNM分期、療後食管x線片評價是影響預後的因素.多因素分析顯示穿孔徵象、腫瘤長度是獨它預後因素.結論 三維適形放療能明顯提高部分食管癌患者的跼部控製率和生存率.療前是否有穿孔徵象、腫瘤長度是影響預後的獨立因素.
목적 분석화평고삼유괄형방료기술대식관암환자적료효급영향예후적인소.방법 회고분석3년간채용삼유괄형방료적132례미수술식관암환자적림상자료,분석기생존솔、국부공제솔화영향예후적인소.결과 전조1、3、4년국부공제솔분별위65.4.5%、52.9%、52.9%.전조1、3、4년생존솔분별위50.7%、29.9%、25.7%,중위생존기위13개월.Ⅰ-Ⅲ기식관암1、2、3、4년생존솔분별위56.7%、36.7%、33.3%、30.3%,Ⅳ기1、2년생존솔분별위35.2%、14.7%,몰유3년생존,중위생존시간분별위15개월화9개월(x2=8.17,P=0.004).종류장도≤8.0 cm、분기균위Ⅰ-Ⅲ기、료전몰유천공정상、접수전정삼유괄형방료적1、3、4년생존솔분별위67.6%、46.3%、40.6%,중위생존시간위27개월.단인소분석현시료전진식정황、천공정상、병변장도、TNM분기、료후식관x선편평개시영향예후적인소.다인소분석현시천공정상、종류장도시독타예후인소.결론 삼유괄형방료능명현제고부분식관암환자적국부공제솔화생존솔.료전시부유천공정상、종류장도시영향예후적독립인소.
Objective To evaluate the efficacy of three-dimensional conformal radiation therapy (3DCRT) for esophageal carcinoma and identify prognostic factors in this patient group.Methods From May 2002 to Jun 2005,132 patients with unresectable or inoperable esophageal cancer were treated with 3DCRT in our hospital.Their chnical data were analyzed retrospectively.ResultsThe 1-and 2-year local control rates was 65.4% and 52.1% in the whole group,respectively.The overall 1-and 2-year survival rate was 50.7% and 32.2% ,respectively.The median survival time was 13 months.The 1-and 2-year survival rate was 56.7%and 36.7% in stageⅠ + Ⅲ ,respectively,with 35.2% and 14.7% in stage IV.The median survival time were 15 months and 9 months for stage Ⅰ +Ⅲ and Ⅳ,respectively(x2 = 8.17,P = 0.004). Of patients with stage Ⅰ + Ⅲ disease who were absent of perforation sign before radiotherapy,with lesion length less than 8.0 cm and whole course given by 3DCRT,the 1-and 2-year survival rate was 73.0% and 49.9%,respectively.Univariate analysis revealed that condition of alimentation,absence of perforation sign, short lesion length,early TNM stage were associated with good survival.Multivariate analysis confirmed that absence of perforation sign and lesion length were independent prognostic factors for survival. Conclusions 3DCRT is effective for esophageal carcinomas in terms of survival and local control.Further improvement could be achieved with muhi-modality treatment.Absence of perforation sign and lesion length are independ ent prognostic factors for survival.
