CAJ | 학술논문

目的探讨CK19、HBME-1、34 βE12在甲状腺乳头状癌(PCT)中的表达及鉴别诊断中的价值.方法复习47例PCT、37例结节性甲状腺肿或滤泡性腺瘤伴良性乳头状增生及40例癌旁正常组织患者的资料,观察HE切片并运用免疫组织化学方法对CK19、HBME-1、34 βE12进行分析.结果 47例PCT均显爪复杂的乳头状结构、纤维化,可见毛玻璃样核、核沟和核内包涵体,免疫组织化学PCT患者CK19的表达阳性率100.0%,HBME-1表达阳性率89.4%,34 βE12表达阳性率42.6%.三者表达明显高于良性乳头状增生及癌旁正常组织(P<0.01).结论 PCT好发于中年女性,诊断时应和形态相似的良性乳头状病变相鉴别.CK19、HBME-1、34 βE12联合检测在鉴别诊断中更有意义.
목적 탐토CK19、HBME-1、34 βE12재갑상선유두상암(PCT)중적표체급감별진단중적개치.방법 복습47례PCT、37례결절성갑상선종혹려포성선류반량성유두상증생급40례암방정상조직환자적자료,관찰HE절편병운용면역조직화학방법대CK19、HBME-1、34 βE12진행분석.결과 47례PCT균현조복잡적유두상결구、섬유화,가견모파리양핵、핵구화핵내포함체,면역조직화학PCT환자CK19적표체양성솔100.0%,HBME-1표체양성솔89.4%,34 βE12표체양성솔42.6%.삼자표체명현고우량성유두상증생급암방정상조직(P<0.01).결론 PCT호발우중년녀성,진단시응화형태상사적량성유두상병변상감별.CK19、HBME-1、34 βE12연합검측재감별진단중경유의의.
Objective To summarize the expression of CK19, HBME-land 34βE12 in papillary carcinoma of the thyroid (PCT) and their differential diagnostic value. Methods Clinical data of papillary carcinoma of the thyroid,nodular goiter and paraeareinoma were reviewed. All HE slides were reexamined and immunostains for CK19, HBME-land 34βEI2 were performed in selected case. Staining results were evaluated. Results Those cases typically showed complex papillary structures and interstitial fibrosis, while nuclear features included ground class appearance, grooves and nuclear pseudoinelusion. The positive rates for CKI9, HBME-1 and 34βE12 in PCT were 100.0 %, 89.4 % and 42.6 % respectively, the differences were statistically significant(P <0.01). Conclusion PCT occurs preferentially in the group of middle-aged women. The diagnosis of PCT should be distinguished from other plesiomorphous benign papillary lesions. Combined detection of CK19, HBME-1, 34βE12 can be most helpful for diagnosis for of PCT.