介入放射学杂志
介入放射學雜誌
개입방사학잡지
JOURNAL OF INTERVENTIONAL RADIOLOGY
2010年
4期
315-317
,共3页
李海伟%徐克%杨柯%刘静%张炳春%夏永辉%郑丰%韩洪波%谭丽丽%洪铎%颜延亭
李海偉%徐剋%楊柯%劉靜%張炳春%夏永輝%鄭豐%韓洪波%譚麗麗%洪鐸%顏延亭
리해위%서극%양가%류정%장병춘%하영휘%정봉%한홍파%담려려%홍탁%안연정
可降解镁合金支架%兔腹主动脉%降解
可降解鎂閤金支架%兔腹主動脈%降解
가강해미합금지가%토복주동맥%강해
bioabsorbable magnesium alloy stent%rabbit%abdominal aorta%degradation
目的 初步评价可降解AZ31镁合金支架在兔主动脉的降解性能.方法 将12枚可降解AZ31镁合金支架置人12只新西兰大白兔腹主动脉中.分别于术后1个月(n=3)、2个月(n=3)、3个月(n=3)及4个月(n=3)处死动物.对支架段血管进行X线照相及病理检查.结果 12只实验兔在随访期存活良好.X线照相及病理显示1个月时支架形态完整,扩张完全;2个月时支架部分支杆降解断裂,失去支撑作用;3个月时大部分支架支杆降解,4个月时所有支架完全降解.支架在兔主动脉中完全降解所需时间为104.5 d.结论 可降解AZ31镁合金支架在兔主动脉中2个月内失去支撑作用,延长支撑时间是未来的研究方向.
目的 初步評價可降解AZ31鎂閤金支架在兔主動脈的降解性能.方法 將12枚可降解AZ31鎂閤金支架置人12隻新西蘭大白兔腹主動脈中.分彆于術後1箇月(n=3)、2箇月(n=3)、3箇月(n=3)及4箇月(n=3)處死動物.對支架段血管進行X線照相及病理檢查.結果 12隻實驗兔在隨訪期存活良好.X線照相及病理顯示1箇月時支架形態完整,擴張完全;2箇月時支架部分支桿降解斷裂,失去支撐作用;3箇月時大部分支架支桿降解,4箇月時所有支架完全降解.支架在兔主動脈中完全降解所需時間為104.5 d.結論 可降解AZ31鎂閤金支架在兔主動脈中2箇月內失去支撐作用,延長支撐時間是未來的研究方嚮.
목적 초보평개가강해AZ31미합금지가재토주동맥적강해성능.방법 장12매가강해AZ31미합금지가치인12지신서란대백토복주동맥중.분별우술후1개월(n=3)、2개월(n=3)、3개월(n=3)급4개월(n=3)처사동물.대지가단혈관진행X선조상급병리검사.결과 12지실험토재수방기존활량호.X선조상급병리현시1개월시지가형태완정,확장완전;2개월시지가부분지간강해단렬,실거지탱작용;3개월시대부분지가지간강해,4개월시소유지가완전강해.지가재토주동맥중완전강해소수시간위104.5 d.결론 가강해AZ31미합금지가재토주동맥중2개월내실거지탱작용,연장지탱시간시미래적연구방향.
Objective To make a preliminary evaluation of the degradation of AZ31 bioabsorbable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits.Methods Twelve AZ31 biodegradable magnesium alloy stents were separately deployed in the infrarenal abdominal aortas of twelve New Zealand white rabbits.Every three experimental rabbits were sacrificed each time at one,two,three and four months after the procedure of stenting.The stenting segment of the aortas were harvested,radiographod and sent for pathologic examination to observe the degradable performance of the stent.Results All animals survived form the operation in the scheduled follow-up period.Radiographically and pathologically,the stents were fully expanded with perfect shape one month after the procedure,and part of the stent struts began to be degraded and fractured in two months,resulting in the loss of its supporting function.Three months after the implantation most stents were corroded.and in four months all the stents become completely destroyed.The estimating time for producing complete degradation of AZ31 magnesium alloy stents in rabbit's aorta was 104.5 days.Conclusion AZ31 bioabsorbable magnesium alloy stents implanted in rabbit abdominal aorta will lose their radial force in two months.How to prolong the functioning time of the implanted stents is the next research target.
