中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
4期
400-403
,共4页
睡眠呼吸暂停低通气综合征,阻塞性%代谢综合征%胰岛素抵抗
睡眠呼吸暫停低通氣綜閤徵,阻塞性%代謝綜閤徵%胰島素牴抗
수면호흡잠정저통기종합정,조새성%대사종합정%이도소저항
Sleep apnea-hypopnea syndrome,obstructive%Metabolic syndrome%Insulin resistance
目的 探讨代谢综合征(Ms)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)可能存在的关系.方法 将82例经多导睡眠图(PSG)监测的肥胖者分为肥胖OSAHS组(55例)和肥胖非OSAHS组(27例),并选取30名正常体重者为正常对照组.测肥胖者的多导睡眠参数呼吸暂停低通气指数(AHI)、手指脉搏血氧饱和度(Spo2);所有受试者均测身高、体重、血压、腰围以及外周循环中代谢参数空腹血糖(FBG)、空腹胰岛素(FINS)、血清尿酸和血脂;以稳态模式评估胰岛素抵抗(HOMA-IR).比较肥胖OSHAS组和肥胖非OSAHS组间MS的患病率、各组间代谢指标的差异性,并分析肥胖OSHAS组各指标之间的相关性.结果 肥胖OSAHS组MS患病率明显高于肥胖非OSAHS组(69.09% us 37.04%,P<0.01).肥胖OSAHS组的收缩压、舒张压、FBG、HOMA-IR均高于肥胖非OSAHS组(P<0.05或P<0.01),而高密度脂蛋白胆固醇(HDL-C)则低于肥胖非OSAHS组(P<0.01).多元逐步回归分析表明舒张压与最低手指脉搏血氧饱和度(LSpo2)呈负相关,FINS、HOMA-IR与AHI呈正相关.结论 OSAHS与MS具有独立相关性,并可能是心脑血管疾病和其它全身性疾病的危险因素.
目的 探討代謝綜閤徵(Ms)與阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)可能存在的關繫.方法 將82例經多導睡眠圖(PSG)鑑測的肥胖者分為肥胖OSAHS組(55例)和肥胖非OSAHS組(27例),併選取30名正常體重者為正常對照組.測肥胖者的多導睡眠參數呼吸暫停低通氣指數(AHI)、手指脈搏血氧飽和度(Spo2);所有受試者均測身高、體重、血壓、腰圍以及外週循環中代謝參數空腹血糖(FBG)、空腹胰島素(FINS)、血清尿痠和血脂;以穩態模式評估胰島素牴抗(HOMA-IR).比較肥胖OSHAS組和肥胖非OSAHS組間MS的患病率、各組間代謝指標的差異性,併分析肥胖OSHAS組各指標之間的相關性.結果 肥胖OSAHS組MS患病率明顯高于肥胖非OSAHS組(69.09% us 37.04%,P<0.01).肥胖OSAHS組的收縮壓、舒張壓、FBG、HOMA-IR均高于肥胖非OSAHS組(P<0.05或P<0.01),而高密度脂蛋白膽固醇(HDL-C)則低于肥胖非OSAHS組(P<0.01).多元逐步迴歸分析錶明舒張壓與最低手指脈搏血氧飽和度(LSpo2)呈負相關,FINS、HOMA-IR與AHI呈正相關.結論 OSAHS與MS具有獨立相關性,併可能是心腦血管疾病和其它全身性疾病的危險因素.
목적 탐토대사종합정(Ms)여조새성수면호흡잠정저통기종합정(OSAHS)가능존재적관계.방법 장82례경다도수면도(PSG)감측적비반자분위비반OSAHS조(55례)화비반비OSAHS조(27례),병선취30명정상체중자위정상대조조.측비반자적다도수면삼수호흡잠정저통기지수(AHI)、수지맥박혈양포화도(Spo2);소유수시자균측신고、체중、혈압、요위이급외주순배중대사삼수공복혈당(FBG)、공복이도소(FINS)、혈청뇨산화혈지;이은태모식평고이도소저항(HOMA-IR).비교비반OSHAS조화비반비OSAHS조간MS적환병솔、각조간대사지표적차이성,병분석비반OSHAS조각지표지간적상관성.결과 비반OSAHS조MS환병솔명현고우비반비OSAHS조(69.09% us 37.04%,P<0.01).비반OSAHS조적수축압、서장압、FBG、HOMA-IR균고우비반비OSAHS조(P<0.05혹P<0.01),이고밀도지단백담고순(HDL-C)칙저우비반비OSAHS조(P<0.01).다원축보회귀분석표명서장압여최저수지맥박혈양포화도(LSpo2)정부상관,FINS、HOMA-IR여AHI정정상관.결론 OSAHS여MS구유독립상관성,병가능시심뇌혈관질병화기타전신성질병적위험인소.
Objective To investigate possible independent association between metabolic syndrome (MS) and obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods According to polysomnography (PSG) examination, 82 obese patients were divided into OSAHS group (n = 55) and non OSAHS group (n = 27) and 30
subjects with normal weight were recruited as the control group. PSG parameters such as AHI (apnea hyponea index), oxygen saturation (Spo2,) in obese patients were measured. MS-associated parameters, such as fasting blood glucose (FBG), fasting insulin (FINS), plasma lipid profile, insulin homeostasis model assessment of insulin resistance (HOMA-IR) and blood pressure, height, body weight, waist circumference, were measured in all cases. The prevalence of MS and the parameters were compared among different groups. The correlations between them were analyzed. Results The prevalence of MS in obese patients with OSAHS was significantly higher than that in obese patients without OSAHS (69.09% vs 37.04%, P <0.01). Systolic blood pressure and diastolic blood pressure (DBP), FBG and HOMA-IR were higher in subjects with OSAHS than those without OSAHS (P <0.05 or P <0.01). Multiple stepwise regression showed that DBP was negatively correlated with Spo2, FINS and HOMA-IR were positively correlated with AHI. Conclusion OSAHS is found to be independently associated with MS, which may be a risk factor of cardiovascular disease and other systemic diseases.
