中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
41期
2894-2896
,共3页
阿尔茨海默病%认知障碍%促肾上腺皮质激素%皮质醇
阿爾茨海默病%認知障礙%促腎上腺皮質激素%皮質醇
아이자해묵병%인지장애%촉신상선피질격소%피질순
Alzheimer disease%Cognitivedeficit%Adreno-cortico-tropic-hormone%Cortisol
目的 探讨阿尔茨海默病(AD)、轻度认知障碍(MCI)患者早晨(8:00am)血清促肾上腺皮质激素(ACTH)、皮质醇水平变化及与疾病的关系.方法 纳入2007年7月5日至2009年3月31日在广州市天河区红十字会医院门诊或内科住院AD、MCI患者及健康志愿者,用化学发光免疫法检测54例AD患者、41例MCI患者及42名健康对照者早晨(8:00am)血清ACTH、皮质醇水平.结果 早晨血清ACTH水平AD组、MCI组及健康对照组分别为(16±5)、(16±5)、(17±4)ng/L,3组早晨血清ACTH比较差异无统计学意义(P＞0.05);早晨血清皮质醇水平AD组、MCI组及健康对照组分别为(595±58)、(568±70)、(410±81)nmol/L,AD组、MCI组早晨血清皮质醇水平显著高于对照组(P＜0.01),MCI组早晨血清皮质醇水平比AD组低,但差异无统计学意义(P＞0.05);等级相关分析,血清皮质醇水平与AD的严重程度呈正相关(P＜0.05);AD组血清皮质醇水平与MMSE评分存在负相关(P＜0.05);性别之间比较血清皮质醇水平AD组、MCI组和健康对照组差异均无统计学意义(均P＞0.05).结论 AD、MCI患者早晨血清ACTH水平无显著改变,皮质醇水平增高,且与AD严重程度呈正相关,与AD患者的MMSE评分存在负相关,性别与血清皮质醇水平无关.
目的 探討阿爾茨海默病(AD)、輕度認知障礙(MCI)患者早晨(8:00am)血清促腎上腺皮質激素(ACTH)、皮質醇水平變化及與疾病的關繫.方法 納入2007年7月5日至2009年3月31日在廣州市天河區紅十字會醫院門診或內科住院AD、MCI患者及健康誌願者,用化學髮光免疫法檢測54例AD患者、41例MCI患者及42名健康對照者早晨(8:00am)血清ACTH、皮質醇水平.結果 早晨血清ACTH水平AD組、MCI組及健康對照組分彆為(16±5)、(16±5)、(17±4)ng/L,3組早晨血清ACTH比較差異無統計學意義(P＞0.05);早晨血清皮質醇水平AD組、MCI組及健康對照組分彆為(595±58)、(568±70)、(410±81)nmol/L,AD組、MCI組早晨血清皮質醇水平顯著高于對照組(P＜0.01),MCI組早晨血清皮質醇水平比AD組低,但差異無統計學意義(P＞0.05);等級相關分析,血清皮質醇水平與AD的嚴重程度呈正相關(P＜0.05);AD組血清皮質醇水平與MMSE評分存在負相關(P＜0.05);性彆之間比較血清皮質醇水平AD組、MCI組和健康對照組差異均無統計學意義(均P＞0.05).結論 AD、MCI患者早晨血清ACTH水平無顯著改變,皮質醇水平增高,且與AD嚴重程度呈正相關,與AD患者的MMSE評分存在負相關,性彆與血清皮質醇水平無關.
목적 탐토아이자해묵병(AD)、경도인지장애(MCI)환자조신(8:00am)혈청촉신상선피질격소(ACTH)、피질순수평변화급여질병적관계.방법 납입2007년7월5일지2009년3월31일재엄주시천하구홍십자회의원문진혹내과주원AD、MCI환자급건강지원자,용화학발광면역법검측54례AD환자、41례MCI환자급42명건강대조자조신(8:00am)혈청ACTH、피질순수평.결과 조신혈청ACTH수평AD조、MCI조급건강대조조분별위(16±5)、(16±5)、(17±4)ng/L,3조조신혈청ACTH비교차이무통계학의의(P＞0.05);조신혈청피질순수평AD조、MCI조급건강대조조분별위(595±58)、(568±70)、(410±81)nmol/L,AD조、MCI조조신혈청피질순수평현저고우대조조(P＜0.01),MCI조조신혈청피질순수평비AD조저,단차이무통계학의의(P＞0.05);등급상관분석,혈청피질순수평여AD적엄중정도정정상관(P＜0.05);AD조혈청피질순수평여MMSE평분존재부상관(P＜0.05);성별지간비교혈청피질순수평AD조、MCI조화건강대조조차이균무통계학의의(균P＞0.05).결론 AD、MCI환자조신혈청ACTH수평무현저개변,피질순수평증고,차여AD엄중정도정정상관,여AD환자적MMSE평분존재부상관,성별여혈청피질순수평무관.
Objective To characterize the response of adrenocortieotropic hormone(ACTH)and cortisol in the patients with Alzheimer disease(AD)and those with mild cognition impairment(MCI).Methods The AD or MCI patients at our department from July 5, 2007 to August 31,2009 were enrolled.The levels of 8am serum ACTH and cortisol were measured by chemiluminescence in 54 AD patients, 41 MCI patients and 42 age -matched controls. Results The serum ACTH values in 3 groups were(16 ±5),(16 ±5)and(17 ±4)ng/L respectively. The serum ACTH values had insignificant changes in 3 groups(P＞0.05). The serum cortisol values were(595 ± 58),(568 ± 70)and(410 ± 81)nmol/L in 3 groups respectively. And the serum cortisol values significantly increased in AD and MCI groups(P ＜0. 01). The levels of serum cortisol in MCI group were lower than those in AD group. But there was no significant difference(P ＞ 0. 05). Through an analysis of rank correlation, the severity of AD had a positive correlation with serum concentration of cortisol(P ＜ 0.05); there was a negative correlation between the serum level of cortisol and the scores of MMSE in AD patients(P ＜ 0.05). There was no significant change of serum level of cortisol for different genders in 3 groups(P ＞ 0.05). Conclusion The level of serum ACTH has no significant change. A high level of serum cortisol is observed in AD and MCI groups. There is a positive correlation between serum level of cortisol and the severity of AD and a negative correlation between serum level of cortisol and the scores.
