CAJ | 학술논문

目的:探讨高脂饲料诱导肥胖抵抗大鼠热能摄入量减少的机制.方法:雌性SD大鼠36只,按体重随机分为高脂实验组和基础对照组,分别给予高脂饲料和基础饲料13w.13w末根据体重将高脂饲料组再分为饮食诱导肥胖(dietary induced obesity, DIO)和饮食诱导肥胖抵抗 (dietary induced obesity resistant, DIO-R)组,比较各组大鼠能量摄入水平,血浆PYY3-36、NPY浓度,下丘脑匀浆NPY含量及下丘脑Y2-R mRNA表达水平的差异.结果:DIO-R大鼠累积热能摄入量低于DIO大鼠(P＜0.01),与对照组相比无显著性差异(P＞0.05);DIO-R大鼠血浆PYY3-36浓度显著高于DIO和对照组大鼠,下丘脑匀浆NPY含量显著低于DIO大鼠(P＜0.01);DIO-R大鼠下丘脑Y2-R mRNA表达水平低于DIO和对照组大鼠(P＜0.01).结论:高脂饲料喂养下,SD大鼠表现为明显的肥胖易感性差异,这种差异与PYY3-36和NPY的食欲调节密切相关,血浆PYY3-36水平的升高与下丘脑NPY水平的下降减少了能量的摄入,从而抑制了体重的过度增加.
목적:탐토고지사료유도비반저항대서열능섭입량감소적궤제.방법:자성SD대서36지,안체중수궤분위고지실험조화기출대조조,분별급여고지사료화기출사료13w.13w말근거체중장고지사료조재분위음식유도비반(dietary induced obesity, DIO)화음식유도비반저항 (dietary induced obesity resistant, DIO-R)조,비교각조대서능량섭입수평,혈장PYY3-36、NPY농도,하구뇌균장NPY함량급하구뇌Y2-R mRNA표체수평적차이.결과:DIO-R대서루적열능섭입량저우DIO대서(P＜0.01),여대조조상비무현저성차이(P＞0.05);DIO-R대서혈장PYY3-36농도현저고우DIO화대조조대서,하구뇌균장NPY함량현저저우DIO대서(P＜0.01);DIO-R대서하구뇌Y2-R mRNA표체수평저우DIO화대조조대서(P＜0.01).결론:고지사료위양하,SD대서표현위명현적비반역감성차이,저충차이여PYY3-36화NPY적식욕조절밀절상관,혈장PYY3-36수평적승고여하구뇌NPY수평적하강감소료능량적섭입,종이억제료체중적과도증가.