上海交通大学学报（医学版）
上海交通大學學報（醫學版）
상해교통대학학보（의학판）
JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY(MEDICAL SCIENCE)
2010年
4期
452-454
,共3页
转录%E2F-4%直肠癌
轉錄%E2F-4%直腸癌
전록%E2F-4%직장암
transcription%E2F-4%rectal cancer
目的 检测中低位直肠癌组织中转录因子E2F-4的表达,并分析其与临床病理学参数和预后的关系.方法 选取临床资料与肿瘤病理标本完整的60例中低位直肠癌患者,所有患者均行直肠癌根治术,另以肠镜活检30例慢性结肠炎的直肠黏膜组织作为对照.免疫组织化学法检测直肠癌组织、癌旁组织及对照直肠黏膜的E2F-4表达,分析其与患者性别、年龄、肿瘤大小、肿瘤分化程度、淋巴结转移、TNM分期和术后转移复发等临床病理参数以及预后的关系.结果 直肠癌组织E2F-4表达显著高于癌旁组织和对照直肠黏膜(P<0.05);直肠癌组织E2F-4表达与肿瘤分化程度、TNM分期、淋巴结转移和术后转移复发有关;直肠癌组织E2F-4表达阴性者术后平均无瘤生存时间显著大于阳性者(P<0.05).结论 转录因子E2F-4与直肠癌生物学行为密切相关,在中低位直肠癌的发生发展中可能发挥癌基因的作用.
目的 檢測中低位直腸癌組織中轉錄因子E2F-4的錶達,併分析其與臨床病理學參數和預後的關繫.方法 選取臨床資料與腫瘤病理標本完整的60例中低位直腸癌患者,所有患者均行直腸癌根治術,另以腸鏡活檢30例慢性結腸炎的直腸黏膜組織作為對照.免疫組織化學法檢測直腸癌組織、癌徬組織及對照直腸黏膜的E2F-4錶達,分析其與患者性彆、年齡、腫瘤大小、腫瘤分化程度、淋巴結轉移、TNM分期和術後轉移複髮等臨床病理參數以及預後的關繫.結果 直腸癌組織E2F-4錶達顯著高于癌徬組織和對照直腸黏膜(P<0.05);直腸癌組織E2F-4錶達與腫瘤分化程度、TNM分期、淋巴結轉移和術後轉移複髮有關;直腸癌組織E2F-4錶達陰性者術後平均無瘤生存時間顯著大于暘性者(P<0.05).結論 轉錄因子E2F-4與直腸癌生物學行為密切相關,在中低位直腸癌的髮生髮展中可能髮揮癌基因的作用.
목적 검측중저위직장암조직중전록인자E2F-4적표체,병분석기여림상병이학삼수화예후적관계.방법 선취림상자료여종류병리표본완정적60례중저위직장암환자,소유환자균행직장암근치술,령이장경활검30례만성결장염적직장점막조직작위대조.면역조직화학법검측직장암조직、암방조직급대조직장점막적E2F-4표체,분석기여환자성별、년령、종류대소、종류분화정도、림파결전이、TNM분기화술후전이복발등림상병리삼수이급예후적관계.결과 직장암조직E2F-4표체현저고우암방조직화대조직장점막(P<0.05);직장암조직E2F-4표체여종류분화정도、TNM분기、림파결전이화술후전이복발유관;직장암조직E2F-4표체음성자술후평균무류생존시간현저대우양성자(P<0.05).결론 전록인자E2F-4여직장암생물학행위밀절상관,재중저위직장암적발생발전중가능발휘암기인적작용.
Objective To detect the expression of transcription factor E2F-4 in middle or lower rectal cancer, and investigate its relationship with clinicopathological parameters and prognosis. Methods Sixty specimens of middle or lower rectal cancer were collected with complete clinical and pathological data, and all the patients were performed radical resection of rectal cancer. Besides, rectal mucosa of 30 patients with chronic colitis examined by enteroscopic biopsy were served as controls. The expression of E2F-4 of rectal cancer tissues, adjacent noncancerous tissues and control rectal mucosa was detected by immunohistochemical method, and its relationship with prognosis and clinicopathological parameters such as gender, age, tumor size, tumor differentiation, lymph node metastasis, TNM staging, post-operative metastasis and recurrence was explored. Results The expression of E2F-4 in rectal cancer tissues was significantly higher than that in adjacent noncancerous tissues and control rectal mucosa (P <0.05). The expression of E2F-4 in rectal cancer tissues was significantly related to tumor differentiation, TNM staging, lymph node metastasis and post-operative metastasis and recurrence. The post-operative tumor-free survival time in patients with negative expression of E2F-4 in rectal cancer tissues was significantly longer than that in patients with positive expression of E2F-4 in rectal cancer tissues (P <0.05). Conclusion The expression of transcription factor E2F-4 is closely related to the biological behavior of rectal cancer, and E2F-4 may be involved in the carcinogenesis and development of middle or lower rectal cancer as oncogene.
