国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
5期
451-454
,共4页
Occludin蛋白%紧密连接%屏障功能%调控机制
Occludin蛋白%緊密連接%屏障功能%調控機製
Occludin단백%긴밀련접%병장공능%조공궤제
Occludin protein%Tight junction%Barrier function%Regulation mechanism
Occludin是紧密连接相关蛋白中最具有代表性的蛋白之一,它封闭细胞旁路,形成紧密连接的基础结构.Occludin的生理功能主要包括栅栏功能和细胞旁屏障功能,其表达低下可导致肺上皮屏障、血脑屏障、肠上皮屏障及血睾屏障的破坏,与多种疾病的发生、发展密切相关.因此,有关Occludin蛋白的调控机制及其临床意义已成为国内外研究的热点.
Occludin是緊密連接相關蛋白中最具有代錶性的蛋白之一,它封閉細胞徬路,形成緊密連接的基礎結構.Occludin的生理功能主要包括柵欄功能和細胞徬屏障功能,其錶達低下可導緻肺上皮屏障、血腦屏障、腸上皮屏障及血睪屏障的破壞,與多種疾病的髮生、髮展密切相關.因此,有關Occludin蛋白的調控機製及其臨床意義已成為國內外研究的熱點.
Occludin시긴밀련접상관단백중최구유대표성적단백지일,타봉폐세포방로,형성긴밀련접적기출결구.Occludin적생리공능주요포괄책란공능화세포방병장공능,기표체저하가도치폐상피병장、혈뇌병장、장상피병장급혈고병장적파배,여다충질병적발생、발전밀절상관.인차,유관Occludin단백적조공궤제급기림상의의이성위국내외연구적열점.
Occludin is one of the best characterized protein in tight junction associated proteins,it seals paracellular way to form the basic structure of tight junction.It performs major functions including fence function and paracellular barrier function.Downregulation of occludin protein might induce the disruption of pulmonary epithelial barrier,blood-brain barrier,intestinal epithelium barrier,blood-testis barrier,which has been proved to be associated with the cause and progress of many diseases.Therefore,the regulation mechanism and clinical significance of occludin protein have been the focus at home and abroad.
