国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
10期
67-69
,共3页
布托啡诺%芬太尼%静脉镇痛%口腔手术
佈託啡諾%芬太尼%靜脈鎮痛%口腔手術
포탁배낙%분태니%정맥진통%구강수술
Butorphanol%fentanyl%Intravenous analgesia%Operation on oral cavity
目的 观察静脉酒石酸布托啡诺复合芬太尼在口腔颌而部手术术后镇痛的临床效果及不良反应.方法 ASAⅠ~Ⅱ级75例择期行口腔颌面部手术病人,随机分成三组,每组25例.A组:单独的酒石酸布托啡诺8mg加生理盐水共120ml;B组:单独的枸橼芬太尼0.8mg加生理盐水共120ml;C组:枸橼酸芬太尼0.4mg与酒石酸布托啡诺4mg加生理盐水共120ml;术毕给予负荷剂量4ml后连接镇痛泵进行自控镇痛(PCIA),术后分别记录6h、24h、48h三个时段的视觉模拟评分(VAS)并观察各种不良反应的发生情况.结果 B组与C组VAS评分显著低于A组(P<0.05),A组与C组不良反应发生率明显少于B组(P<0.05).结论 枸橼酸芬太尼0.4mg与酒石酸布托啡诺4mg加生理盐水共120ml(C组)镇痛效果确切,不良反应较少,是口腔颌面部手术术后静脉镇痛治疗的良好选择之一.
目的 觀察靜脈酒石痠佈託啡諾複閤芬太尼在口腔頜而部手術術後鎮痛的臨床效果及不良反應.方法 ASAⅠ~Ⅱ級75例擇期行口腔頜麵部手術病人,隨機分成三組,每組25例.A組:單獨的酒石痠佈託啡諾8mg加生理鹽水共120ml;B組:單獨的枸櫞芬太尼0.8mg加生理鹽水共120ml;C組:枸櫞痠芬太尼0.4mg與酒石痠佈託啡諾4mg加生理鹽水共120ml;術畢給予負荷劑量4ml後連接鎮痛泵進行自控鎮痛(PCIA),術後分彆記錄6h、24h、48h三箇時段的視覺模擬評分(VAS)併觀察各種不良反應的髮生情況.結果 B組與C組VAS評分顯著低于A組(P<0.05),A組與C組不良反應髮生率明顯少于B組(P<0.05).結論 枸櫞痠芬太尼0.4mg與酒石痠佈託啡諾4mg加生理鹽水共120ml(C組)鎮痛效果確切,不良反應較少,是口腔頜麵部手術術後靜脈鎮痛治療的良好選擇之一.
목적 관찰정맥주석산포탁배낙복합분태니재구강합이부수술술후진통적림상효과급불량반응.방법 ASAⅠ~Ⅱ급75례택기행구강합면부수술병인,수궤분성삼조,매조25례.A조:단독적주석산포탁배낙8mg가생리염수공120ml;B조:단독적구연분태니0.8mg가생리염수공120ml;C조:구연산분태니0.4mg여주석산포탁배낙4mg가생리염수공120ml;술필급여부하제량4ml후련접진통빙진행자공진통(PCIA),술후분별기록6h、24h、48h삼개시단적시각모의평분(VAS)병관찰각충불량반응적발생정황.결과 B조여C조VAS평분현저저우A조(P<0.05),A조여C조불량반응발생솔명현소우B조(P<0.05).결론 구연산분태니0.4mg여주석산포탁배낙4mg가생리염수공120ml(C조)진통효과학절,불량반응교소,시구강합면부수술술후정맥진통치료적량호선택지일.
Objective To observe the postoperative analgesia effects and adverse reaction of the intrave-nous butorphanol tartrate combine with fentanyl for oral and maxillofacial surgery. Method ASA Ⅰ-Ⅱ Level 75 patients, selected for the oral and maxillofacial surgery, were divided into 3 groups randomly. Group A intravenous injected only 8mg butorphanol tratrate with physiological saline 120ml, Group B injected 0.8mg fentanyl citrate with physiological saline 120ml and group C injected 0.4mg fentanyl Citrate and 4rag butorphauol tartrate together with physiological saline 120ml. After operation, they were given loading dose 4ml, and then connected to analgesic pump for patient controlled analgesia (PCIA). The visual analogue scale (VAS) and adverse reaction of drugs was recorded 6h, 24h and 48h later. Results The VAS of group B and C are lower than that of group A obviously (P<0.05). The adverse reaction in group A and group C is distinctly less than that in group B (P<0.05). Conclusion The analgesic effect of 0.4mg Fentanyl Citrate and 4mg Butorphanol Tartrate together with physiological saline 120ml is obviously, and the adverse reaction is less. It is one of the good choices for intravenous analgesic treatment after oral and maxilllofacial surgery.