CAJ | 학술논문

间充质干细胞是非造血系的多能干细胞,能从许多组织如脐带血、肝、脾、骨髓、脂肪组织、羊水、骨膜和胚胎等分离得到,在一定条件诱导下可分化为骨、软骨、肌肉、韧带、腱、肝、神经、血管内皮和脂肪等组织的细胞,能够表达多种表型包括黏附分子和趋化因子受体等,同时具有免疫耐受性,因此具有定向迁移运输到靶组织的潜能和免疫抑制特性,在心血管、神经、血液、外科损伤等多项领域的疾病中具有广泛应用前景,为组织修复工程和基因治疗开辟了新的途径.本文就间充质干细胞的表型、免疫学特性、归巢潜能等作简要的综述.
간충질간세포시비조혈계적다능간세포,능종허다조직여제대혈、간、비、골수、지방조직、양수、골막화배태등분리득도,재일정조건유도하가분화위골、연골、기육、인대、건、간、신경、혈관내피화지방등조직적세포,능구표체다충표형포괄점부분자화추화인자수체등,동시구유면역내수성,인차구유정향천이운수도파조직적잠능화면역억제특성,재심혈관、신경、혈액、외과손상등다항영역적질병중구유엄범응용전경,위조직수복공정화기인치료개벽료신적도경.본문취간충질간세포적표형、면역학특성、귀소잠능등작간요적종술.
Mesenehymal stem cells CMSCS are nonhematopoietie stromal cells that are capable of differentiating into, and contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon and adipose. MSCs have been isolated from human first- and second-trimester fetal blood, liver, spleen, bone marrow, adipose tissue, amniotie fluid, periosteum and embryo. Not only can they express many phynotypes involving adhesion molecules and chemokine receptors, but also have character of immune tolerance, so they have potential of migration and transportation to target issue and feature of immune suppressing. There are wide application prospects for a number of areas in the cardiovascular, neurological, blood, surgical injury and other diseases. The current review describes the phynotypes, the immune tolerance and the potential for homing of MSCs.