CAJ | 학술논문

目的探讨慢性丙型肝炎患者体内TNF-α、视黄醇结合蛋白4(RBP-14)、脂联素(ADP)与稳态模型法胰岛素抵抗指数(HOMA-IR)之间的关系,为进一步研究慢性丙型肝炎患者胰岛素抵抗的机制提供理论依据.方法选择69例慢性丙型肝炎患者和50名体检正常者,测定各组空腹血糖、空腹胰岛素、血清TNF-α、RBP-4、ADP水平,计算HOMA-IR.结果慢性丙型肝炎患者组体内空腹血糖、空腹胰岛素、HOMA-IR均高于正常组(t=3.75、t=3.43、t=3.68,P＜0.05);血清TNF-α、RBP-4水平均高于正常组,ADP水平低于正常组(t=14.30、t=5.86、t=-4.76,P＜0.05).多元线性回归显示,慢性丙型肝炎患者体内HOMA-IR与RBP-4呈负相关,与ADP呈正相关(P＜0.05).结论 RBP-4、ADP是慢性丙型肝炎患者体内胰岛素抵抗的独立影响因素,在慢性丙型肝炎患者发生胰岛素抵抗过程中起重要作用.
목적 탐토만성병형간염환자체내TNF-α、시황순결합단백4(RBP-14)、지련소(ADP)여은태모형법이도소저항지수(HOMA-IR)지간적관계,위진일보연구만성병형간염환자이도소저항적궤제제공이론의거.방법 선택69례만성병형간염환자화50명체검정상자,측정각조공복혈당、공복이도소、혈청TNF-α、RBP-4、ADP수평,계산HOMA-IR.결과 만성병형간염환자조체내공복혈당、공복이도소、HOMA-IR균고우정상조(t=3.75、t=3.43、t=3.68,P＜0.05);혈청TNF-α、RBP-4수평균고우정상조,ADP수평저우정상조(t=14.30、t=5.86、t=-4.76,P＜0.05).다원선성회귀현시,만성병형간염환자체내HOMA-IR여RBP-4정부상관,여ADP정정상관(P＜0.05).결론 RBP-4、ADP시만성병형간염환자체내이도소저항적독립영향인소,재만성병형간염환자발생이도소저항과정중기중요작용.
Objective To evaluate the relations between serum TNF-α,retinol-binding protein 4(RBP-4),adiponectin(ADP) and homeostasis model assessment of insulin resistance(HOMA-IR) in HCV-infeeted subjects,to provide a basis theory for studying on the mechanism of insulin resistance in patients with chronic hepatitis C.Methods The serum levels of TNF-α,RBP-4,ADP,fast glucose and fast insulin of 69 patients with chronic hepatitis C and 50 normal subjects were measured,HOMA-IR of them were separately computed.Results The patients with chronic hepatitis C had higher fasting plasma glucose,fasting insulin and HOMA-IR than that of normal subjects(t=3.75,3.43,3.68,P＜0.05).The serum TNF-α and RBP-4 level were higher in patients with chronic hepatitis C,while ADP level was lower than that in normal subjects(t=14.30,5.86,-4.76,P＜0.05).Multivariate regression analysis showed that insulin resistance index of patients with chronic hepatitis C had a negative relationship with RBP-4 and a positive relationship with ADP(P＜0.05).Conclusions RBP-4 and ADP are independent factors of insulin resistance in chronic hepatitis C patients.They play important roles in the process of insulin resistance.