CAJ | 학술논문

目的调查烟台地区妇女宫颈感染高危人乳头瘤病毒(HR-HPV)的状况,建立本地区妇女HR-HPV感染的流行病学资料库.方法选取2009年3月至2011年6月在我院妇科门诊就诊的妇女3690例,常规采取宫颈脱落细胞,PCR结合导流杂交技术使基因芯片杂交显色,检测包括13种高危亚型的21种HPV亚型,同时对其中自愿进行阴道镜活检的445例患者取宫颈样本做病理检查.结果 3690例患者中,HPV阳性721例,占19.54％,其中HR-HPV622例,占16.86％,HR-HPV感染者中,单一感染426例,多重感染196例,各HR-HPV亚型感染排在前三位的是HPV16(30.06％)、HPV58(17.36％)和HPV52(16.40％),各亚型阳性率和多重感染率差异均有统计学意义(x2=617.447,P＜0.01; x2=28.045,P＜0.01).受检人群根据年龄分为五组:≤20、21～30、31 ～40、41～50和＞50岁组,各年龄组HR-HPV感染率分别为21.88％、18.67％、15.63％、15.26％、17.05％( x2=6.692,P＞0.05)；不同季度HR-HPV感染率分别为17.81％、17.05％、16.67％、15.92％(x2=1.141,P＞0.05)；各病理组HR-HPV亚型以HPV16为主.结论烟台地区妇女HR-HPV感染以HPV16亚型为主,其次为HPV58和HPV52,不同年龄组感染呈双高峰特点,HPV16在宫颈癌的发生中起重要作用.
목적 조사연태지구부녀궁경감염고위인유두류병독(HR-HPV)적상황,건립본지구부녀HR-HPV감염적류행병학자료고.방법 선취2009년3월지2011년6월재아원부과문진취진적부녀3690례,상규채취궁경탈락세포,PCR결합도류잡교기술사기인심편잡교현색,검측포괄13충고위아형적21충HPV아형,동시대기중자원진행음도경활검적445례환자취궁경양본주병리검사.결과 3690례환자중,HPV양성721례,점19.54％,기중HR-HPV622례,점16.86％,HR-HPV감염자중,단일감염426례,다중감염196례,각HR-HPV아형감염배재전삼위적시HPV16(30.06％)、HPV58(17.36％)화HPV52(16.40％),각아형양성솔화다중감염솔차이균유통계학의의(x2=617.447,P＜0.01; x2=28.045,P＜0.01).수검인군근거년령분위오조:≤20、21～30、31 ～40、41～50화＞50세조,각년령조HR-HPV감염솔분별위21.88％、18.67％、15.63％、15.26％、17.05％( x2=6.692,P＞0.05)；불동계도HR-HPV감염솔분별위17.81％、17.05％、16.67％、15.92％(x2=1.141,P＞0.05)；각병리조HR-HPV아형이HPV16위주.결론 연태지구부녀HR-HPV감염이HPV16아형위주,기차위HPV58화HPV52,불동년령조감염정쌍고봉특점,HPV16재궁경암적발생중기중요작용.
Objective To investigate high risk human papillomavirus (HR-HPV)infection of women in Yantai and establish the epidemic data of HR-HPV infection in the area.Methods A total of 3690 gynecological outpatients from March 2009 to June 2011 were involved,21 types of HPV DNA including 13 HR-HPV types were detected with women's cervical scrapes by PCR amplification,flow-through hybridization and gene chip technology,and 445 volunteers were detected by colposcopic biopsy.Results In 3690 patients,721 women were HPV positive( 19.54％ )and 622 patients were HR-HPV infection( 16.86％ ).In HR-HPV patients,426 patients were single infection and 196 were multiple infection.HPV16,58,52 prevalence rates were 30.06％,17.36％ and 16.40％,significant differences were found in both infection rate of HR-HPV ( x2 =617.447,P ＜ 0.01 ) and multiple infection rate ( x2 =28.045,P ＜ 0.01 ) among HR-HPV genotypes.The patients were classified into 5 age groups:≤20,21-30,31-40,41-50 and＞ 50 year-old,according to the age groups.HR-HPV prevalence rates were 21.88％,18.67％,15.63％,15.26％ and 17.05％ respectively.There were no statistical differences in 5 age groups( x2 =6.692,P ＞ 0.05).HR-HPV prevalence rates of different quarters were 17.81％,17.05％,16.67％ and 15.92％ (x2=1.141,P ＞ 0.05).HPV16 was the priority HR-HPV type in the pathological groups.Conclusions HPV16 was the predominant type followed by HPV 58 and 52 in Yantai area.HR-HPV infection rate showed a double peak characteristics in different age groups.HPV16 type played an important role in the occurrence of cervical cancer.