CAJ | 학술논문

目的评估垂体生长激素(GH)腺瘤的侵袭性及经鼻蝶窦显微外科手术对其近期疗效的影响.方法收集并分析22例GH腺瘤患者的临床资料,分别检测术前和术后第3天、术后1个月血清GH平,按照Wilson改良Hardy分类方法判断肿瘤侵袭性.所有患者均由同一手术者进行经鼻蝶窦显微外科手术治疗,分析侵袭性与非侵袭性腺瘤的临床疗效.结果 22例GH腺瘤患者,侵袭性腺瘤11例,非侵袭性腺瘤11例.侵袭性与非侵袭性GH腺瘤患者术后好转率差异无统计学意义(P＞0.05).GH≤50μg/L患者与＞50μg/L 患者术后治愈缓解率差异无统计学意义(P＞0.05).结论 GH腺瘤侵袭性与近期手术疗效可能无差异.
목적 평고수체생장격소(GH)선류적침습성급경비접두현미외과수술대기근기료효적영향.방법 수집병분석22례GH선류환자적림상자료,분별검측술전화술후제3천、술후1개월혈청GH평,안조Wilson개량Hardy분류방법판단종류침습성.소유환자균유동일수술자진행경비접두현미외과수술치료,분석침습성여비침습성선류적림상료효.결과 22례GH선류환자,침습성선류11례,비침습성선류11례.침습성여비침습성GH선류환자술후호전솔차이무통계학의의(P＞0.05).GH≤50μg/L환자여＞50μg/L 환자술후치유완해솔차이무통계학의의(P＞0.05).결론 GH선류침습성여근기수술료효가능무차이.
Objective To assess the recent effect of the invasiveness and transsphenoidal microsurgical operation in the treatment of growth hormone-secreting adenom tumor.Methods The data of 22 patients with growth hormone(GH) adenomas were collected.All patients were tested preoperative GH level and that within the first 3 days,30 days following surgery.The invasiveness of pituitary adenomas was judged according to Hardy's classification scheme modified by Wilson.Results There were 22 patients with GH-secreting pituitary adenomas,8 males and 14 females,11 patients with invasive adenomas and 11 patients with noninvasive adenomas.The remission rate between the patients with invasive adenomas and the patients with non-invasive adenomas had no statistically significant difference (P ＞ 0.05 ).The postoperative remission rate of patients with GH values ≤ 50μg/L was no significantly lower than that of ＞ 50μg/L( P ＞ 0.05).Conclusion The recent effects of operation were not significantly different with the invasiveness of tumor.