CAJ | 학술논문

目的建立二甲基甲酰胺(DMF)接触工人皮肤污染量的测定方法,并对DMF接触工人皮肤污染情况进行研究.方法选择不同岗位的37名DMF接触工人,随机分成异丙醇组(16人)和去离子水组(21人),分别以异丙醇和去离子水为擦拭溶剂,采用气相色谱法测定DMF的皮肤污染量,同时测定工人班末尿中甲基甲酰胺(NMF)含量,并对皮肤污染总量与尿中NMF进行相关分析.结果异丙醇组均能检测出DMF含量,去离子水组均未检出DMF,样品图谱中其他杂峰与DMF峰能完全分离,无干扰.湿法岗位工人皮肤污染总量最高[(2.844±1.31)mg],后处理岗位[(2.50±0.95)mg]和干法岗位[(1.95±0.61)mg]次之,后处理三版印刷、干法配料和湿法配料岗位工人经呼吸道累积接触剂量分别为351.3、201.3、135.2 mg.3个岗位空气中DMF平均浓度为60.2、89.6、156.4 mg/m3,皮肤DMF污染总量与尿中NMF无明显相关,差异无统计学意义(r=0.176,P>0.05).结论异丙醇是测定DMF皮肤污染较有效的擦拭溶剂;当工作场所空气中DMF浓度高于职业接触限值时,DMF以呼吸道吸收为丰要途径,但其皮肤吸收也不容忽视.
목적 건립이갑기갑선알(DMF)접촉공인피부오염량적측정방법,병대DMF접촉공인피부오염정황진행연구.방법 선택불동강위적37명DMF접촉공인,수궤분성이병순조(16인)화거리자수조(21인),분별이이병순화거리자수위찰식용제,채용기상색보법측정DMF적피부오염량,동시측정공인반말뇨중갑기갑선알(NMF)함량,병대피부오염총량여뇨중NMF진행상관분석.결과 이병순조균능검측출DMF함량,거리자수조균미검출DMF,양품도보중기타잡봉여DMF봉능완전분리,무간우.습법강위공인피부오염총량최고[(2.844±1.31)mg],후처리강위[(2.50±0.95)mg]화간법강위[(1.95±0.61)mg]차지,후처리삼판인쇄、간법배료화습법배료강위공인경호흡도루적접촉제량분별위351.3、201.3、135.2 mg.3개강위공기중DMF평균농도위60.2、89.6、156.4 mg/m3,피부DMF오염총량여뇨중NMF무명현상관,차이무통계학의의(r=0.176,P>0.05).결론 이병순시측정DMF피부오염교유효적찰식용제;당공작장소공기중DMF농도고우직업접촉한치시,DMF이호흡도흡수위봉요도경,단기피부흡수야불용홀시.
Objective To establish a method for the determination of dimethylformamide(DMF) and investigate dermal contamination and absorption among workers occupationally exposed to DMF. Method 37 workers exposed to DMF were divided randomly into two groups. DMF was washed down by isopropyl alcohol in A group (16 workers) and water in B group(21 workers).Gas chromatography was used for the quantification of dermal contamination and N-methylformamide(NMF) in urine, correlative study was done between them. Results DMF could be detected in all samples in A group, but could not be detected in B group. The miscel-laneous peaks could be completely separated from the DMF peak in the sample spectrum, without matual in-ference. The highest degree of total dermal contamination was observed in wet spinning workshop[(2.84±1.31 ) ing], postprocessing workshop[(2.50±0.95) mg] and dry spinning workshop[( 1.95±0.61) mg] were lower. The respiratory cumulative exposure dosages were 351.3, 201.3 and 135.2 mg respectively. The average DMP concentration in air of the third printing processing workshop, the dry spirning workshop and the wet spinning workshop was 60.2, 89.6, 156.4 mg/m3 respectively, and the respiratory tract contamination in the workers of the three workshops were 135.2, 201.3 and 351.3 mg respectively. There was statistical independence between the quantification of total dermal contamination and NMF in urine (r=0.176,P>0.05). Conclusion Isopropyl alcohol is the effective washing solvent.When the concentration of DMF in workplace air is above the occupa-tional exposure limit, respiratory tract absorption is the principal pathway of DMF absorption,but dermal con-tamination of DMF should not be ignored.