CAJ | 학술논문

目的探讨TRIB3基因多态性与颈动脉粥样硬化的关系及可能的机制.方法采用彩色多普勒超声诊断仪及聚合酶链式反应-限制性片段长度多态性( polymerase chain reaction-restrictive fragment length polymorphism,PCR-RFLP)法对随机选取高血压患者200例,正常对照200例进行检测.结果与对照组相比,高血压组平均内膜-中层厚度(intima- media thickness,IMT)明显升高(t=39.223,P＜0.01)；与AA基因型携带者相比,GG基因型携带者平均IMT增大(t=22.235,P＜0.001)；IMT增厚危险因素Logistic回归分析,AG+ GG基因型进入回归方程(OR=2.116,95％CI:1.045～4.721,P=0.031),腰围、收缩压和空腹血糖升高是IMT增厚的危险因素.结论携带TRIB3基因+251A/G多态性G等位基因的高血压患者具有颈动脉粥样硬化的易患性.
목적 탐토TRIB3기인다태성여경동맥죽양경화적관계급가능적궤제.방법 채용채색다보륵초성진단의급취합매련식반응-한제성편단장도다태성( polymerase chain reaction-restrictive fragment length polymorphism,PCR-RFLP)법대수궤선취고혈압환자200례,정상대조200례진행검측.결과 여대조조상비,고혈압조평균내막-중층후도(intima- media thickness,IMT)명현승고(t=39.223,P＜0.01)；여AA기인형휴대자상비,GG기인형휴대자평균IMT증대(t=22.235,P＜0.001)；IMT증후위험인소Logistic회귀분석,AG+ GG기인형진입회귀방정(OR=2.116,95％CI:1.045～4.721,P=0.031),요위、수축압화공복혈당승고시IMT증후적위험인소.결론 휴대TRIB3기인+251A/G다태성G등위기인적고혈압환자구유경동맥죽양경화적역환성.
Objective To investigate the effect of TRIB3 gene polymorphism on carotid atherosclerosis in hypertensive patients. Methods A total of 400 subjects were recruited in.the study including control group ( n =200) and hypertension group ( n =200). These 400 subjects were genotyped using polymerase chain reaction-restrictive fragment length polymorphism ( PCR-RFIP). All of them underwent carotid ultrasonography.Results Compared to the controls,the hypertensive patients showed increased IMT ( t =39.223,P ＜ 0.01) ; The CG allele carriers had more thickened IMT than the AA allele carriers ( t =22.235,P ＜ 0.001) ; The Logistic regression analysis suggested that the G allele is the risk factors for carotid atherosclerosis ( OR =2.116, 95％ CI:1.045 ～4.721, P =0.031). Furthermore,waist circumference,systolic blood pressure and fasting blood glucose are risk factors for thickened IMT.Conclusion Those hypertensive patients carrying TRIB3 gene +251A/G polymorphism G allele were susceptible to carotid atherosclerosis <英文关键词>=Hypertension;Carotid atherosclerosis ;TRIB3 ;Polymorphism