中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
1期
64-67
,共4页
葛明旭%孔大伟%滕宏涛%王洪杰%孙平
葛明旭%孔大偉%滕宏濤%王洪傑%孫平
갈명욱%공대위%등굉도%왕홍걸%손평
垂体腺瘤%视力%经鼻蝶入路
垂體腺瘤%視力%經鼻蝶入路
수체선류%시력%경비접입로
Pituitary adenoma%Vision%Transnasal transsphenoidal
目的 探讨经鼻蝶入路垂体腺瘤切除术对视力改善的作用及影响术后视力改善的相关因素,建立回归方程.方法 左眼视力与右眼视力分别进行比较,术后视力与术前视力比较采用配对t检验,对相关因素应用多分类有序反应变量的logistic回归模型进行分析.结果 配对t检验表明,经鼻蝶入路垂体腺瘤切除术后双眼视力较术前均有明显改善[左眼:术前视力(0.8±0.6),术后视力(0.9±0.6),t=-4.716,P=0.005；右眼:术前视力(0.9±0.5)、术后视力(1.0±0.5),t=-4.976,P=0.004]；应用累积logistic回归模型筛选出两个对术后视力有影响的变量为肿瘤长径和术前视力.肿瘤长径越大,术后视力改善越明显(Wald x2=0.047,OR=2.240,P=0.047)；术前视力下降程度越重,术后视力改善越明显(Wald x2=9.684,OR=0.010,P=0.001).而患者年龄、性别、病理类型、切除程度、视力下降出现时间对术后视力改善均无影响.结论 ·经鼻蝶入路垂体腺瘤切除术能明显改善患者视力,改善程度与肿瘤直径和术前视力下降的程度有关.
目的 探討經鼻蝶入路垂體腺瘤切除術對視力改善的作用及影響術後視力改善的相關因素,建立迴歸方程.方法 左眼視力與右眼視力分彆進行比較,術後視力與術前視力比較採用配對t檢驗,對相關因素應用多分類有序反應變量的logistic迴歸模型進行分析.結果 配對t檢驗錶明,經鼻蝶入路垂體腺瘤切除術後雙眼視力較術前均有明顯改善[左眼:術前視力(0.8±0.6),術後視力(0.9±0.6),t=-4.716,P=0.005；右眼:術前視力(0.9±0.5)、術後視力(1.0±0.5),t=-4.976,P=0.004]；應用纍積logistic迴歸模型篩選齣兩箇對術後視力有影響的變量為腫瘤長徑和術前視力.腫瘤長徑越大,術後視力改善越明顯(Wald x2=0.047,OR=2.240,P=0.047)；術前視力下降程度越重,術後視力改善越明顯(Wald x2=9.684,OR=0.010,P=0.001).而患者年齡、性彆、病理類型、切除程度、視力下降齣現時間對術後視力改善均無影響.結論 ·經鼻蝶入路垂體腺瘤切除術能明顯改善患者視力,改善程度與腫瘤直徑和術前視力下降的程度有關.
목적 탐토경비접입로수체선류절제술대시력개선적작용급영향술후시력개선적상관인소,건립회귀방정.방법 좌안시력여우안시력분별진행비교,술후시력여술전시력비교채용배대t검험,대상관인소응용다분류유서반응변량적logistic회귀모형진행분석.결과 배대t검험표명,경비접입로수체선류절제술후쌍안시력교술전균유명현개선[좌안:술전시력(0.8±0.6),술후시력(0.9±0.6),t=-4.716,P=0.005；우안:술전시력(0.9±0.5)、술후시력(1.0±0.5),t=-4.976,P=0.004]；응용루적logistic회귀모형사선출량개대술후시력유영향적변량위종류장경화술전시력.종류장경월대,술후시력개선월명현(Wald x2=0.047,OR=2.240,P=0.047)；술전시력하강정도월중,술후시력개선월명현(Wald x2=9.684,OR=0.010,P=0.001).이환자년령、성별、병리류형、절제정도、시력하강출현시간대술후시력개선균무영향.결론 ·경비접입로수체선류절제술능명현개선환자시력,개선정도여종류직경화술전시력하강적정도유관.
Objective To investigate the factors affecting the vision recovery after transnasal transsphenoidal pituitary adenoma resection.Methods The vision of the left eyes and the right eyes were compared respectively.The vision after and before the operation was also compared by using paired t-test,related factors were analyzed by multiple variable logistic regression model.Results The paired t-test indicated that both eyes' visions were improved after transnasal transsphenoidal pituitary adenoma resection( P ＜0.01 ).The tumor diameter and the vision before operation were two factors affecting the post-operative visions by cumulative logistic regression model.The larger the diameters of the tumors were,the better the vision recoveries after operation( Wald x2 =0.047,OR =2.240,P =0.047).Worse vision lose before operation came up with a better recovery after operation ( Wald x2 =9.684,OR =0.010,P =0.001 ) ; however,age,gender,pathological category,the extent of tumor removal and the time of the vision loss have no significant affects on the vision recovery after operation.Conclusion The transnasal transsphenoidal pituitary adenoma resection can improve the vision of the patients,and the degree which would to be improved is correlated with the tumor diameter and the vision lose before operation.
