中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
9期
724-728
,共5页
马轩%王红梅%李娟%王新国%塔吉古丽%张丽丽%梁登攀%王梦卉%李南方
馬軒%王紅梅%李娟%王新國%塔吉古麗%張麗麗%樑登攀%王夢卉%李南方
마헌%왕홍매%리연%왕신국%탑길고려%장려려%량등반%왕몽훼%리남방
原发性醛固酮增多症%代谢综合征%高血压%醛固酮
原髮性醛固酮增多癥%代謝綜閤徵%高血壓%醛固酮
원발성철고동증다증%대사종합정%고혈압%철고동
Primary aldosteronism%Metabolic syndrome%Hypertension%Aldosterone
目的 评价原发性醛固酮增多症(原醛症)患者中代谢综合征(MS)的患病率及其与醛固酮水平的关系。方法 收集2008年10月至2010年7月本院诊治的216例原醛症患者的临床资料并进行回顾性统计,分析该人群中MS的患病情况。结果 (1)原醛症患者的MS患病率为47.69%;在MS各组分中,超重或肥胖、高甘油三酯(TG)血症、糖调节受损、低高密度脂蛋白胆固醇( HDL-C)血症及糖尿病的检出率依次为51.13%、22.52%、19.62%、3.82%和2.94%,中重度高血压为91.87%。(2)在MS各组分中(除高血压外),位于前3位的组合依次为超重或肥胖+高TG血症、超重或肥胖+低HDL-C血症以及超重或肥胖+糖尿病,检出率分别为35.19%、15.74%和11.57%。(3)随着血醛固酮水平的升高,超重或肥胖及糖调节受损检出率逐渐增高;高TG血症、低HDL-C血症以及MS检出率在醛固酮最高水平组高于低水平组。(4)原醛症患者中MS患病率维吾尔族(64.0%)高于汉族(45.3%),哈萨克族(42.9%)则低于汉族,差异有统计学意义(P<0.05)。结论原醛症患者MS患病率高,MS及其组分患病率随醛固酮水平增加而增高。
目的 評價原髮性醛固酮增多癥(原醛癥)患者中代謝綜閤徵(MS)的患病率及其與醛固酮水平的關繫。方法 收集2008年10月至2010年7月本院診治的216例原醛癥患者的臨床資料併進行迴顧性統計,分析該人群中MS的患病情況。結果 (1)原醛癥患者的MS患病率為47.69%;在MS各組分中,超重或肥胖、高甘油三酯(TG)血癥、糖調節受損、低高密度脂蛋白膽固醇( HDL-C)血癥及糖尿病的檢齣率依次為51.13%、22.52%、19.62%、3.82%和2.94%,中重度高血壓為91.87%。(2)在MS各組分中(除高血壓外),位于前3位的組閤依次為超重或肥胖+高TG血癥、超重或肥胖+低HDL-C血癥以及超重或肥胖+糖尿病,檢齣率分彆為35.19%、15.74%和11.57%。(3)隨著血醛固酮水平的升高,超重或肥胖及糖調節受損檢齣率逐漸增高;高TG血癥、低HDL-C血癥以及MS檢齣率在醛固酮最高水平組高于低水平組。(4)原醛癥患者中MS患病率維吾爾族(64.0%)高于漢族(45.3%),哈薩剋族(42.9%)則低于漢族,差異有統計學意義(P<0.05)。結論原醛癥患者MS患病率高,MS及其組分患病率隨醛固酮水平增加而增高。
목적 평개원발성철고동증다증(원철증)환자중대사종합정(MS)적환병솔급기여철고동수평적관계。방법 수집2008년10월지2010년7월본원진치적216례원철증환자적림상자료병진행회고성통계,분석해인군중MS적환병정황。결과 (1)원철증환자적MS환병솔위47.69%;재MS각조분중,초중혹비반、고감유삼지(TG)혈증、당조절수손、저고밀도지단백담고순( HDL-C)혈증급당뇨병적검출솔의차위51.13%、22.52%、19.62%、3.82%화2.94%,중중도고혈압위91.87%。(2)재MS각조분중(제고혈압외),위우전3위적조합의차위초중혹비반+고TG혈증、초중혹비반+저HDL-C혈증이급초중혹비반+당뇨병,검출솔분별위35.19%、15.74%화11.57%。(3)수착혈철고동수평적승고,초중혹비반급당조절수손검출솔축점증고;고TG혈증、저HDL-C혈증이급MS검출솔재철고동최고수평조고우저수평조。(4)원철증환자중MS환병솔유오이족(64.0%)고우한족(45.3%),합살극족(42.9%)칙저우한족,차이유통계학의의(P<0.05)。결론원철증환자MS환병솔고,MS급기조분환병솔수철고동수평증가이증고。
Objective To explore the prevalence of metabolic syndrome (MS) in patients with primary aldosteronism(PA) and the correlation with plasma aldosterone concentration. Methods The incidence of MS was retrospectively analyzed in 216 patients with PA from October 2008 to July 2010. Results( 1 ) The prevalence of MS was 47. 69% in the patients with PA. As the individual components of MS, the incidence of overweight/obesity,raised blood triglyceride ( TG ) level, impaired glucose regulation ( IGR), lowered high-density lipoprotein-cholesterol ( HDL-C), and diabetes mellitus( DM ) was 51.13%, 22. 52%, 19.62%, 3.82%, and 2.94%, respectively. (2)The most common combination of MS components was overweight/obesity+high TG, followed by overweight/obesity+ lowered HDL-C, and overweight/obesity + DM, with the incidence of 35. 19%, 15.74%, and 11.57%,respectively. (3) The incidence of overweight/obesity and IGR was raised progressively with the increasing plasma aldosterone level. (4) The prevalence of MS was significantly lower in Han patients (45.3%) than in Uygur ( 64. 0% ), but higher than in Kazakh (42. 9%, both P<0. 05 ). Conclusions The prevalence of MS in patients with PA was high. The prevalences of MS and its components were gradually rising with plasma aldosterone level.