CAJ | 학술논문

目的评价甲型H1N1流行性感冒(简称流感)疫苗在大规模人群预防接种中的安全性.方法 2009年9-12月期间北京市共接种甲型H1N1流感疫苗2 113 280人,通过监测系统收集疑似预防接种不良反应患者的个案信息,采用描述性方法对一般反应及异常反应特征进行流行病学分析.结果北京市共报告疑似预防接种不良反应612例,其中不良反应321例,偶合症203例,心因性反应82例,待定6例.与疫苗相关的不良反应中,异常反应、一般反应报告发生率分别为5.54/10万(117/2 113 280)、9.65/10万(204/2 113 280);严重异常反应报告率为0.19/10万(4/2 113 280).城区、近郊及远郊县的不良反应报告率分别为:16.87/10万(36/213 519)、17.81/10万(187/1 049 817)及11.53/10万(98/849 944).不同年龄组异常反应、一般反应报告率介于3.65/10万(6/164 604)～8.99/10万(27/300 176)和0.61/10万(1/164 604)～22.06/10万(85/385 275)之间.117例异常反应中主要临床诊断为过敏性皮疹(107例),204例一般反应主要临床诊断为发热(176例).91.90%(295/321)不良反应发生于接种24 h以内,所有病例转归良好.结论本市甲型H1N1流感疫苗接种后报告的不良反应以过敏及发热为主,不良反应类型及严重程度与预期一致,未发现新的或罕见的不良反应.
목적 평개갑형H1N1류행성감모(간칭류감)역묘재대규모인군예방접충중적안전성.방법 2009년9-12월기간북경시공접충갑형H1N1류감역묘2 113 280인,통과감측계통수집의사예방접충불량반응환자적개안신식,채용묘술성방법대일반반응급이상반응특정진행류행병학분석.결과 북경시공보고의사예방접충불량반응612례,기중불량반응321례,우합증203례,심인성반응82례,대정6례.여역묘상관적불량반응중,이상반응、일반반응보고발생솔분별위5.54/10만(117/2 113 280)、9.65/10만(204/2 113 280);엄중이상반응보고솔위0.19/10만(4/2 113 280).성구、근교급원교현적불량반응보고솔분별위:16.87/10만(36/213 519)、17.81/10만(187/1 049 817)급11.53/10만(98/849 944).불동년령조이상반응、일반반응보고솔개우3.65/10만(6/164 604)～8.99/10만(27/300 176)화0.61/10만(1/164 604)～22.06/10만(85/385 275)지간.117례이상반응중주요림상진단위과민성피진(107례),204례일반반응주요림상진단위발열(176례).91.90%(295/321)불량반응발생우접충24 h이내,소유병례전귀량호.결론 본시갑형H1N1류감역묘접충후보고적불량반응이과민급발열위주,불량반응류형급엄중정도여예기일치,미발현신적혹한견적불량반응.
Objective To evaluate the safety of 2009 influenza A ( H1N1 ) vaccine based on mass immunization initiative in Beijing. Method There were 2 113 280 people were vaccinated during September to December 2009. The information of adverse events following immunization ( AEFI ) was collected through surveillance system ,and descriptive methodology was used for data analysis. Results A Total of 612 AEFI cases were reported, among which there were 321 vaccine reaction cases following immunization, 203 coincidental illness cases ,82 psychogenic reaction cases, and 6 pending cases. The rates of rare reactions and common reactions associated with vaccination were respectively 5.54/100 000 (117/2 113 280 ) and 9. 65/100 000 (204/2 113 280). The rate of serious rare reaction was 0. 19/100 000 (4/2 113 280). The rates of vaccine reactions in urban,suburb and county were 16. 87/100 000 (36/213 519) ,17. 81/100 000 ( 187/1 049 817) and 11.53/100 000 (98/849 944) ,respectively. The rates of rare reaction and common reaction in different age groups were between 3.65/100 000 (6/164 604) to 8.99/100 000 (27/300 176),and between 0. 61/100 000 (1/164 604) to 22. 06/100 000 (85/385 275 ). The 117 rear vaccine reaction cases were mainly allergic reaction (107 cases),and the 204 common vaccine reaction cases were mainly fever (176 cases ). There were 91.90% (295/321) vaccine reactions occurred within 24 hours of administration,and all cases had improved consequence. Conclusion The mostly symptoms of AEFI cases during the period of 2009 influenza A ( H1 N1 ) vaccinoprophylaxis were anaphylaxis and fever. The types of adverse reactions and the level of serious events are consistent with the anticipation. There were no rear or new events occurred.