中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2012年
2期
143-147
,共5页
迟静%张群%翟成凯%张红%韩淑芬%刘亚琪%周思宇
遲靜%張群%翟成凱%張紅%韓淑芬%劉亞琪%週思宇
지정%장군%적성개%장홍%한숙분%류아기%주사우
高脂血症%膳食%干预性研究%氧化性应激%抗氧化剂%复合全谷豆粗杂粮
高脂血癥%膳食%榦預性研究%氧化性應激%抗氧化劑%複閤全穀豆粗雜糧
고지혈증%선식%간예성연구%양화성응격%항양화제%복합전곡두조잡량
Hyperlipidemias%Diet%Intervention studies%Oxidative stress%Antioxidants%Compound whole grain
目的 研究复合全谷豆粗杂粮抗氧化复合链对脂代谢异常人群氧化应激的影响.方法 2008年3月至2009年3月,从南京市3个主城区采用多阶段分层随机抽样抽得418例常住汉族(45～75岁)高脂血症患者,按准实验设计,根据社区、血脂和氧化指标分层随机分为干预组(212例)与对照组(206例).干预组给予粗杂粮干预和健康教育,对照组仅给予健康教育.干预周期为1年,干预前后各进行1次医学体检,测量计算BMI、腰臀比(WHR)；检测血脂以及血清总抗氧化能力(T-AOC)、丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)等氧化应激指标.分析干预前后体态、生化指标与氧化应激指标的关联.结果 干预后干预组的BMI[(25.53±2.77)kg/m2]、WHR(0.82±0.03)、TC[(4.60±0.98)mmol/L]、TG[(1.26±0.88)mmol/L]低于对照组[(26.60 ±3.18)kg/m2、0.93 ±0.05、(4.97±1.02)mmol/L、(1.98±1.11)mmol/L](P值均＜0.05)；而HDL-C[(1.34±0.26)mmol/L]高于对照组[(1.18±0.17)mmol/L](P＜0.05)；干预后干预组的T-AOC(19.52±0.81)、SOD[(85.42±21.65)U/ml]、GSH-Px[(128.26±33.65)μmol/L]高于对照组[11.11 ±1.30、(78.68±30.48)U/ml、(118.48±24.19)μmol/L](P值均＜0.05)；而MDA[(1.78±1.16)nmol/ml]低于对照组[(2.12±1.37)mmol/L](P ＜0.05)；T-AOC与TC、TG及BMI呈负相关(r值分别为-0.258、-0.266、-0.230,P值均＜0.05),与HDL-C呈正相关(r=0.194,P＜0.05)；SOD与TC、TG、BMI呈负相关(r值分别为-0.282、-0.311、-0.217,P值均＜0.05),与HDL-C呈正相关(r=0.169,P＜0.05).结论 复合全谷豆粗杂粮膳食干预明显改善脂代谢异常人群的代谢状况.人体常用代谢指标和体内氧化应激反应水平存在关联.
目的 研究複閤全穀豆粗雜糧抗氧化複閤鏈對脂代謝異常人群氧化應激的影響.方法 2008年3月至2009年3月,從南京市3箇主城區採用多階段分層隨機抽樣抽得418例常住漢族(45～75歲)高脂血癥患者,按準實驗設計,根據社區、血脂和氧化指標分層隨機分為榦預組(212例)與對照組(206例).榦預組給予粗雜糧榦預和健康教育,對照組僅給予健康教育.榦預週期為1年,榦預前後各進行1次醫學體檢,測量計算BMI、腰臀比(WHR)；檢測血脂以及血清總抗氧化能力(T-AOC)、丙二醛(MDA)、超氧化物歧化酶(SOD)和穀胱甘肽過氧化物酶(GSH-Px)等氧化應激指標.分析榦預前後體態、生化指標與氧化應激指標的關聯.結果 榦預後榦預組的BMI[(25.53±2.77)kg/m2]、WHR(0.82±0.03)、TC[(4.60±0.98)mmol/L]、TG[(1.26±0.88)mmol/L]低于對照組[(26.60 ±3.18)kg/m2、0.93 ±0.05、(4.97±1.02)mmol/L、(1.98±1.11)mmol/L](P值均＜0.05)；而HDL-C[(1.34±0.26)mmol/L]高于對照組[(1.18±0.17)mmol/L](P＜0.05)；榦預後榦預組的T-AOC(19.52±0.81)、SOD[(85.42±21.65)U/ml]、GSH-Px[(128.26±33.65)μmol/L]高于對照組[11.11 ±1.30、(78.68±30.48)U/ml、(118.48±24.19)μmol/L](P值均＜0.05)；而MDA[(1.78±1.16)nmol/ml]低于對照組[(2.12±1.37)mmol/L](P ＜0.05)；T-AOC與TC、TG及BMI呈負相關(r值分彆為-0.258、-0.266、-0.230,P值均＜0.05),與HDL-C呈正相關(r=0.194,P＜0.05)；SOD與TC、TG、BMI呈負相關(r值分彆為-0.282、-0.311、-0.217,P值均＜0.05),與HDL-C呈正相關(r=0.169,P＜0.05).結論 複閤全穀豆粗雜糧膳食榦預明顯改善脂代謝異常人群的代謝狀況.人體常用代謝指標和體內氧化應激反應水平存在關聯.
목적 연구복합전곡두조잡량항양화복합련대지대사이상인군양화응격적영향.방법 2008년3월지2009년3월,종남경시3개주성구채용다계단분층수궤추양추득418례상주한족(45～75세)고지혈증환자,안준실험설계,근거사구、혈지화양화지표분층수궤분위간예조(212례)여대조조(206례).간예조급여조잡량간예화건강교육,대조조부급여건강교육.간예주기위1년,간예전후각진행1차의학체검,측량계산BMI、요둔비(WHR)；검측혈지이급혈청총항양화능력(T-AOC)、병이철(MDA)、초양화물기화매(SOD)화곡광감태과양화물매(GSH-Px)등양화응격지표.분석간예전후체태、생화지표여양화응격지표적관련.결과 간예후간예조적BMI[(25.53±2.77)kg/m2]、WHR(0.82±0.03)、TC[(4.60±0.98)mmol/L]、TG[(1.26±0.88)mmol/L]저우대조조[(26.60 ±3.18)kg/m2、0.93 ±0.05、(4.97±1.02)mmol/L、(1.98±1.11)mmol/L](P치균＜0.05)；이HDL-C[(1.34±0.26)mmol/L]고우대조조[(1.18±0.17)mmol/L](P＜0.05)；간예후간예조적T-AOC(19.52±0.81)、SOD[(85.42±21.65)U/ml]、GSH-Px[(128.26±33.65)μmol/L]고우대조조[11.11 ±1.30、(78.68±30.48)U/ml、(118.48±24.19)μmol/L](P치균＜0.05)；이MDA[(1.78±1.16)nmol/ml]저우대조조[(2.12±1.37)mmol/L](P ＜0.05)；T-AOC여TC、TG급BMI정부상관(r치분별위-0.258、-0.266、-0.230,P치균＜0.05),여HDL-C정정상관(r=0.194,P＜0.05)；SOD여TC、TG、BMI정부상관(r치분별위-0.282、-0.311、-0.217,P치균＜0.05),여HDL-C정정상관(r=0.169,P＜0.05).결론 복합전곡두조잡량선식간예명현개선지대사이상인군적대사상황.인체상용대사지표화체내양화응격반응수평존재관련.
Objective To explore the influence of compound whole grain complex antioxidant chain on oxidative stress to the hyperlipidemia population.Methods From March 2008 to March 2009,418 hyperlipemia residents(45 to 75 years of age)of Han group were screened from 3 main districts in Nanjing,according to the community,blood lipids and oxidative indicators,stratified into intervention and control group by quasi-experimental design.The intervention group(212 individuals)were provided with compound whole grain and health education while only health education was provided for the control group(206 individuals).Body mass index(BMI),waist-to-hip ratio(WHR),total cholesterol(TC),triglyceride(TG)and high density lipoprotein cholesterol(HDL-C)and oxidative indicators(including T-AOC,MDA,SOD,GSH-Px)were measured before and after the one-year intervention period.Analyses of the correlation between posture,biochemical markers and oxidative stress indicators before and after intervention were carried out.Results After intervention,BMI((25.53 ± 2.77)kg/m2),WHR(0.82 ± 0.03),TC((4.60 ± 0.98)mmol/L),TG((1.26 ± 0.88)mmol/L)in the intervention group were decreased significantly compared to the levels of BMI((26.60 ± 3.18)kg/m2),WHR(0.93 ±0.05),TC((4.97 ± 1.02)mmol/L),TG ((1.98± 1.11)mmol/L)in the control group(all P values ＜ 0.05); while HDL-C((1.34 ±0.26)mmol/L)in the intervention group was increased significantly compared to the level of HDL-C ((1.18 ± 0.17)mmol/L)in the control group(P ＜ 0.05); After intervention,levels of T-AOC(19.52 ±0.81),SOD((85.42 ± 21.65)U/ml)and GSH-Px((128.26 ± 33.65)μ mol/L)were increased significantly compared to the levels of T-AOC(11.11 ± 1.30),SOD((78.68 ±30.48)U/ml)and GSH-Px ((118.48±24.19)μmol/L)in the control group(all P values ＜ 0.05); while MDA((1.78 ±.1.16)nmol/ml)decreased significantly compared to the level of MDA((2.12 ± 1.37)nmol/ml in the control group(P ＜0.05); Pearson product moment correlation analysis showed that:T-AOC with TC,TG,BMI showed a negative correlation(r values were-0.258,-0.266,-0.230,respectively,all P values ＜0.05),while with HDL-C was a positive correlation(r values was 0.194,P ＜ 0.05); SOD with TC,TG,BMI showed a negative correlation(r values were-0.282,-0.311,-0.217,respectively,all P values ＜0.05),while with HDL-C was a positive correlation(r values was 0.169,P ＜ 0.05).Conclusion Compound whole grain could improve lipid metabolism to the hyperlipidemia population.There was a correlation between common human metabolism and the levels of oxidative stress.
