CAJ | 학술논문

根据乳腺大汗腺癌、小管癌、黏液癌、浸润导管癌、单纯癌和髓样癌组织Fourier变换红外光谱酰胺I带的去卷积和拟合分析，获得组织中蛋白质二级结构的数目及其组成。结果表明：这些组织中蛋白质二级结构的数目及其组成存在着显著的差异，并与组织的类型、分化、坏死等密切相关。其中，髓样癌的差异性最大；高分化癌中螺旋结构的含量及非典型螺旋和α-螺旋含量的比值均比低分化癌的相应值高；肿瘤边缘坏死的乳腺癌组织也表现出明显的差异。乳腺癌组织蛋白质二级结构的分析对乳腺癌组织的表征和评价具有重要的意义。
근거유선대한선암、소관암、점액암、침윤도관암、단순암화수양암조직Fourier변환홍외광보선알I대적거권적화의합분석，획득조직중단백질이급결구적수목급기조성。결과표명：저사조직중단백질이급결구적수목급기조성존재착현저적차이，병여조직적류형、분화、배사등밀절상관。기중，수양암적차이성최대；고분화암중라선결구적함량급비전형라선화α-라선함량적비치균비저분화암적상응치고；종류변연배사적유선암조직야표현출명현적차이。유선암조직단백질이급결구적분석대유선암조직적표정화평개구유중요적의의。
Considerable different compositions of the secondary structure of protein, determined by curve-fitting analysis of the amide I bands in the FTIR spectra, are found among human breast apocrine, tubular, mucinous, invasive infiltrating ductal, simplex and medullary carcinoma tissues. Among those tissues, medullary carcinoma tissue appears extremely difference, well-differentiated carcinomas have higher proportions of helices, and higher ratios between the proportions of atypical helix and α-helix than poorly differentiated carcinomas ; obvious compositional differences are also observed between carcinoma with and without tumor necrosis. The secondary structures of proteins may have important implication for characterizing and evaluating breast carcinoma tissues.