CAJ | 학술논문

目的利用计算机仿真手段,研究缺血对折返波活动状态的影响及其与心律失常的关系.方法利用Noble 98心室肌细胞动力学数学模型,通过算子分裂和自适应时间步长的方法对心肌组织传导模型的偏微分方程求数值解.通过在二维组织中降低细胞内ATP浓度,减小Na+电导和增加细胞外K+浓度模拟细胞的缺血状态.采用垂直场方法诱导螺旋波.结果仿真结果显示螺旋波在局部严重缺血时表现出3种不同的形态,而对局部中度缺血,只出现了2种形态.当缺血面积处于某临界状态时,有波断裂的发生.但在大面积局部缺血时,螺旋波呈现典型的围绕障碍物旋转的功能性折返.结论缺血面积和程度对室速/室颤的发生具有影响.缺血面积增加有利于螺旋波的维持,增大了室速发生和保持的可能性.在一定缺血面积和缺血程度下,螺旋波易发生断裂,促进了室速向室颤的转化.
목적이용계산궤방진수단,연구결혈대절반파활동상태적영향급기여심률실상적관계.방법이용Noble 98심실기세포동역학수학모형,통과산자분렬화자괄응시간보장적방법대심기조직전도모형적편미분방정구수치해.통과재이유조직중강저세포내ATP농도,감소Na+전도화증가세포외K+농도모의세포적결혈상태.채용수직장방법유도라선파.결과방진결과현시라선파재국부엄중결혈시표현출3충불동적형태,이대국부중도결혈,지출현료2충형태.당결혈면적처우모림계상태시,유파단렬적발생.단재대면적국부결혈시,라선파정현전형적위요장애물선전적공능성절반.결론결혈면적화정도대실속/실전적발생구유영향.결혈면적증가유리우라선파적유지,증대료실속발생화보지적가능성.재일정결혈면적화결혈정도하,라선파역발생단렬,촉진료실속향실전적전화.
Objective To study ischemic effects on reentrant activities and cardiac arrhythmias using a computational approach. Method The Noble 98 mathematical model of ventricular cell was used in the study. The operator splitting and adaptive time step methods were utilized to integrate the partial differential equations in cardiac conduction models. The ischemic cells were simulated by decreasing the intracellular ATP concentration, reducing the Na+ conductance, and increasing the extracellular K+ concentration in a two-dimensional tissue. Spiral waves were initiated by the cross field technique. Result The results showed that spiral waves in local severe ischemia displayed three different morphologies,whereas in moderate ischemia only two kinds of wave forms exhibited. When the degree of ischemia reached a critical value, the reentrant wave could break. But for larger areas of ischemia spiral wave formed a typical functional reentry around the obstacle. Conclusion The study demonstrates that size and level of ischemia have effects on VTs and VFs. Large ischemic area is beneficial for maintenance of spiral wave and can provide a high probability in the genesis of VTs. Spiral waves can easily break up and degenerate into VFs under critical area or level of ischemia.