CAJ | 학술논문

背景:目前国内外对于乳腺癌生活质量的研究较多,但抗抑郁药对于乳腺癌抑郁症患者生活质量的影响还不清楚.目的:探讨氟西汀对乳腺癌抑郁症患者生活质量的影响.设计:以患者为研究对象,前后对照的观察对比研究.单位:两所大学医学心理学和精神医学专业研究机构和一所市级医院的心理科.对象:中国医科大学附属第一医院、中国医科大学附属第二医院和大连市肿瘤医院住院的乳腺癌术后患者63例,平均(50±9)岁.干预:对63例乳腺癌抑郁症患者进行8周的氟西汀治疗,采用副反应量表(TESS)和相关实验室检查评价氟西汀对乳腺癌抑郁症患者抑郁、焦虑的安全性,采用世界卫生组织生存质量评定量表(WHOQOL)评价患者用药前后的生活质量.主要观察指标:①WHOQOL各项指标评分.②副作用及不良反应.结果:用药8周后患者生活质量中的生理(16.30±2.17)、心理(14.41±1.85)、独立性(16.90±1.53)三个领域评分明显高于入组前(13.61±2.46,12.98±2.65,13.65±2.45),差异有显著性意义(t=6.52,P＜0.01;t=2.41,P＜0.05和t=8.93,P＜0.01).患者用药期间未出现明显药物副反应.结论:氟西汀能明显改善乳腺癌患者的生活质量,且治疗期间副反应较少.
배경:목전국내외대우유선암생활질량적연구교다,단항억욱약대우유선암억욱증환자생활질량적영향환불청초.목적:탐토불서정대유선암억욱증환자생활질량적영향.설계:이환자위연구대상,전후대조적관찰대비연구.단위:량소대학의학심이학화정신의학전업연구궤구화일소시급의원적심이과.대상:중국의과대학부속제일의원、중국의과대학부속제이의원화대련시종류의원주원적유선암술후환자63례,평균(50±9)세.간예:대63례유선암억욱증환자진행8주적불서정치료,채용부반응량표(TESS)화상관실험실검사평개불서정대유선암억욱증환자억욱、초필적안전성,채용세계위생조직생존질량평정량표(WHOQOL)평개환자용약전후적생활질량.주요관찰지표:①WHOQOL각항지표평분.②부작용급불량반응.결과:용약8주후환자생활질량중적생리(16.30±2.17)、심리(14.41±1.85)、독립성(16.90±1.53)삼개영역평분명현고우입조전(13.61±2.46,12.98±2.65,13.65±2.45),차이유현저성의의(t=6.52,P＜0.01;t=2.41,P＜0.05화t=8.93,P＜0.01).환자용약기간미출현명현약물부반응.결론:불서정능명현개선유선암환자적생활질량,차치료기간부반응교소.
BACKGROUND: There are many studies on the quality of life (QOL) of patients with breast cancer at home and abroad at present. But the effect of antidepressants on the QOL of depressive patients with breast cancer is not clear yet.OBJECTIVE: To investigate the effect of fluoxetine on the QOL of depressive patients with breast cancer.DESIGN: A self-controlled and observational comparative study of taking the patient as the subjects.SETTING: The research institute of medical psychology and psychiatric specialty in two universities and a psychiatric department in a city hospital.PARTICIPANTS: Sixty-three female post-operative patients with breast cancer hospitalized in the First Affiliated Hospital and Second Affiliated Hospital of China Medical University and Dalian Tumor Hospital, with an average age of (50 ± 9) years.INTERVENTIONS: Sity-three depressive patients with breast cancer were treated with fluoxetine for 8 weeks. Treatment emergent symptom scale (TESS) and relative laboratory examinations were used to evaluate the safety of fluoxetine to depression and anxiety of depressive patients with breast cancer. QOL of WHO scale was used to assess the QOL of the patients before and after administration.MAIN OUTCOME MEASURS:①Score of every index of QOL of WHO;②Side effects and adverse effects.RESULTS: The scores of physiology, psychology and independence in QOLafter 8 weeks' administration(16.30 ±2.17, 14.41 ± 1.85, 16. 90 ± 1.53)were significantly higher than those before grouping (13.61 ±2.46,12.98 ± 2.65, 13.65 ± 2.45) ( t = 6.52, P ＜ 0.01; t = 2.41, P＜ 0.05; t= 8.93, P ＜ 0.01 ). No obvious side effect was observed during administration.CONCLUSION: Fluoxetine can significantly improve the QOL of patients with breast cancer and there are fewer side effects during the treatment.