成都医学院学报
成都醫學院學報
성도의학원학보
JOURNAL OF CHENGDU MEDICAL COLLEGE
2007年
3期
174-176,183
,共4页
脑钠素%充血性心力衰竭%血清%诊断
腦鈉素%充血性心力衰竭%血清%診斷
뇌납소%충혈성심력쇠갈%혈청%진단
brain natriuretic peptide%congestive heart failure%serum%diagnosis
目的 探讨血清脑钠素(BNP)水平在评价充血性心力衰竭(CHF)中的应用价值,以及观察不同病因的心衰患者血清BNP的水平变化.方法 选取100例CHF患者,并根据纽约心脏协会(NYHA)分级标准分为Ⅱ-Ⅳ级,选取100名心功能正常者为实验对照,采用全自动免疫分析仪(罗氏2010型)电化学发光法(E-CLA)测定各组HF患者血清BNP水平.结果 CHF病人血清BNP为4 745.49±3 698.70 ng/ml,高于对照组66.18±44.30 ng/ml,两者相比差异具有统计学意义(P<0.05),且BNP浓度随着心功能分级的增加也增加;不同病因(高血压、冠心病、风心病)所致的CHF患者血清BNP水平(NYHAⅢ、Ⅳ级)的差异无统计学学意义(P>0.05),但NYHAⅡ级各病因组间BNP水平差异有显著性(P<0.05).结论 CHF患者血清BNP水平显著增高,且随着NYHA分级增加而增加,可作为评价CHF严重程度的客观指标.
目的 探討血清腦鈉素(BNP)水平在評價充血性心力衰竭(CHF)中的應用價值,以及觀察不同病因的心衰患者血清BNP的水平變化.方法 選取100例CHF患者,併根據紐約心髒協會(NYHA)分級標準分為Ⅱ-Ⅳ級,選取100名心功能正常者為實驗對照,採用全自動免疫分析儀(囉氏2010型)電化學髮光法(E-CLA)測定各組HF患者血清BNP水平.結果 CHF病人血清BNP為4 745.49±3 698.70 ng/ml,高于對照組66.18±44.30 ng/ml,兩者相比差異具有統計學意義(P<0.05),且BNP濃度隨著心功能分級的增加也增加;不同病因(高血壓、冠心病、風心病)所緻的CHF患者血清BNP水平(NYHAⅢ、Ⅳ級)的差異無統計學學意義(P>0.05),但NYHAⅡ級各病因組間BNP水平差異有顯著性(P<0.05).結論 CHF患者血清BNP水平顯著增高,且隨著NYHA分級增加而增加,可作為評價CHF嚴重程度的客觀指標.
목적 탐토혈청뇌납소(BNP)수평재평개충혈성심력쇠갈(CHF)중적응용개치,이급관찰불동병인적심쇠환자혈청BNP적수평변화.방법 선취100례CHF환자,병근거뉴약심장협회(NYHA)분급표준분위Ⅱ-Ⅳ급,선취100명심공능정상자위실험대조,채용전자동면역분석의(라씨2010형)전화학발광법(E-CLA)측정각조HF환자혈청BNP수평.결과 CHF병인혈청BNP위4 745.49±3 698.70 ng/ml,고우대조조66.18±44.30 ng/ml,량자상비차이구유통계학의의(P<0.05),차BNP농도수착심공능분급적증가야증가;불동병인(고혈압、관심병、풍심병)소치적CHF환자혈청BNP수평(NYHAⅢ、Ⅳ급)적차이무통계학학의의(P>0.05),단NYHAⅡ급각병인조간BNP수평차이유현저성(P<0.05).결론 CHF환자혈청BNP수평현저증고,차수착NYHA분급증가이증가,가작위평개CHF엄중정도적객관지표.
Objective To explore the value of Brain Natriuretic pepfide (BNP) in estimating the degree of seriousness of congestive heart failure (HF) and study BNP level of CHF caused by various cardiovascular diseases.Methods 100 patients with CHF were divided into three classes (classⅠ,Ⅱ and Ⅳ)by New York Heart Association (NYHA) functional classification Standard. 100 healthy individuals were selected into control group.Serum BNP concentration Were measured by electrochemical luminescence assay (Elecsys 2010,Roche Diagnostics).Results Mean serum BNP concentration of patients with CHF was 4 745.49±3 698.70 ng/ml,which was higher significantly than that of normal control (66.18±44.30ng/ml).Moreover,the growth in BNP level was increased with NYHA functional classification:class Ⅳ (1 0251±9 326.8 ng/ml) >class Ⅲ(1 239±1 063.8 ng/ml) > class Ⅱ (167.4±143.4 ng/ml),which was statistically significant (P<0.05).It was statistically significant among three groups of pathogenesis (hypertension,coronary heart disease and rheumatic heart disease) of CHF in the NYHA classification level Ⅱ,whereas there was no difference between class Ⅲ and class Ⅳ.Conclusion Serum BNP level can be applied as a biomarker for congestive heart failure and can estimate the severity of CHF.
