CAJ | 학술논문

目的检测PI3K、AKT、MRP蛋白在胰腺癌组织中的表达,探讨它们的临床病理学意义及三者之间的相关性.方法采用免疫组织化学法检测43例胰腺癌组织、9例CP组织和8例正常胰腺组织中PI3K、AKT、MRP蛋白的表达.结果 PI3K、AKT、MRP在胰腺癌组织中的阳性表达率分别为46.51%、55.81%和39.53%,均高于CP和正常胰腺组织中的表达(P<0.01和P<0.05).PI3K、AKT蛋白表达与胰腺癌的淋巴结转移和TNM分期相关(P<0.05).胰腺癌组织中MRP与PBK均异常表达者为32.56%,均正常表达者为46.51%,两者呈显著正相关(r=0.581,P<0.01);MRP与AKT均异常表达者为32.56%,均正常表达者为37.21%,两者呈显著正相关(r=0.432,P<0.05);PI3K与AKT均异常表达者为37.21%,均正常表达者32.56%,两者呈显著正相关(r=0.306,P<0.05).结论胰腺癌组织PI3K、AKT和MRP蛋白表达上调,三者呈正相关.P13K和AKT的表达与淋巴结转移及TNM分期有关.
목적 검측PI3K、AKT、MRP단백재이선암조직중적표체,탐토타문적림상병이학의의급삼자지간적상관성.방법 채용면역조직화학법검측43례이선암조직、9례CP조직화8례정상이선조직중PI3K、AKT、MRP단백적표체.결과 PI3K、AKT、MRP재이선암조직중적양성표체솔분별위46.51%、55.81%화39.53%,균고우CP화정상이선조직중적표체(P<0.01화P<0.05).PI3K、AKT단백표체여이선암적림파결전이화TNM분기상관(P<0.05).이선암조직중MRP여PBK균이상표체자위32.56%,균정상표체자위46.51%,량자정현저정상관(r=0.581,P<0.01);MRP여AKT균이상표체자위32.56%,균정상표체자위37.21%,량자정현저정상관(r=0.432,P<0.05);PI3K여AKT균이상표체자위37.21%,균정상표체자32.56%,량자정현저정상관(r=0.306,P<0.05).결론 이선암조직PI3K、AKT화MRP단백표체상조,삼자정정상관.P13K화AKT적표체여림파결전이급TNM분기유관.
Objective To investigate the expressions of PI3K, AKT and MRP protein in pancreatic carcinoma and to determine the clinicopathological significance and the correlation among three protein expressions. Methods The immunohistochemical method was used to detect the expressions of PI3K, AKT and MRP in forty three pancreatic carcinoma, nine chronic pancreatitis and eight normal pancreatic tissue samples. Results The positive expression rates of PI3K, AKT and MRP were 46.51%, 55.81% and 39.53%, respectively in pancreatic carcinoma, which were remarkably higher than those in normal pancreatic tissue and in chronic pancreatitis (P<0.01 and P<0.05, respectively). The aberrant expression of PI3K, AKT and MRP were associated with lymph node metastasis and TNM stages (P<0.05). The abnormal expression rate in both MRP and PI3K was 32.56%, the normal expression rate of both MRP and PI3K was 46.51%, and there was positive correlation between the expression of MRP and PI3K(r=0.581, P<0.01). The abnormal expression rate of both MRP and AKT was 32.56%, the normal expression rate was 37.21%, and there was a positive correlation between MRP and PI3K (r=0.432,P<0.05). The abnormal expression rate of both MRP and PI3K was 37.21%, the normal expression rate of both MRP and PI3K was 32.56%, there was also a positive correlation between MRP and PI3K (r=0.306,P<0.05). Conclusions The expressions of PI3K, AKT and MRP were up-regulated in pancreatic carcinoma. The expressions of PI3K and AKT may be related to the lymph node metastasis and TNM staging.