CAJ | 학술논문

目的探讨结直肠癌腹膜种植转移的危险因素.方法回顾性分析2003年1月至2008年12月南方医院普通外科收治的873例结直肠癌患者的临床病理资料,研究结直肠癌腹膜种植转移与临床和病理因素的关系.结果 873例患者中,腹膜种植转移97例(11.1%).单因素分析显示,患者的年龄(P=0.032)、肿瘤大小(P=0.001)、肿瘤分化程度(P=0.008)、肠壁浸润深度(P=0.000)、淋巴结转移(P=0.000)、术前CEA(P=0.003)和血清糖链抗原19-9(CA19-9)水平(P=0.009)与结直肠癌腹膜种植转移有关.Logistic多因素回归分析显示,肠壁浸润深度、淋巴结转移以及术前CEA和CA19-9水平与结直肠癌腹膜种植转移有关(均P＜0.05).结论肠壁浸润深度、淋巴结转移、术前CEA及CA19-9水平是影响结直肠癌腹膜种植转移的独立危险因素.
목적 탐토결직장암복막충식전이적위험인소.방법 회고성분석2003년1월지2008년12월남방의원보통외과수치적873례결직장암환자적림상병리자료,연구결직장암복막충식전이여림상화병리인소적관계.결과 873례환자중,복막충식전이97례(11.1%).단인소분석현시,환자적년령(P=0.032)、종류대소(P=0.001)、종류분화정도(P=0.008)、장벽침윤심도(P=0.000)、림파결전이(P=0.000)、술전CEA(P=0.003)화혈청당련항원19-9(CA19-9)수평(P=0.009)여결직장암복막충식전이유관.Logistic다인소회귀분석현시,장벽침윤심도、림파결전이이급술전CEA화CA19-9수평여결직장암복막충식전이유관(균P＜0.05).결론 장벽침윤심도、림파결전이、술전CEA급CA19-9수평시영향결직장암복막충식전이적독립위험인소.
Objective To investigate risk factors associated with peritoneal metastasis in colorectal cancer. Methods Clinicopathological data of 873 patients with colorectal cancer treated at the Nanfang Hospital of Southern Medical University from January 2003 to December 2008 were retrospectively analyzed. The associations between peritoneal metastasis and cliniopathological factors were evaluated by univariate analysis including independent-samples t test and x2 test, and multivariable logistic regression analysis. Results Univariate analysis showed that age(P=0.032), tumor size(P=0.001 ),tumor differentiation (P=0.008), depth of bowel wall invasion ( P=0.000 ), lymph node metastasis ( P=0.000 ),serum carcinoembryonic antigen (CEA) level(P=0.003), and serum carbohydrate antigen 19-9(CA19-9)level (P=0.009) were associated with peritoneal metastasis. On multivariable logistic regression analysis,depth ofbowelwallinvasion, lymph node metastasis, serum CEA level and CA19-9 level remained as significant risk factors (all P＜0.05). Conclusion Depth of bowel wall invasion, lymph node metastasis,serum CEA level, and CA19-9 level are risk factors for peritoneal metastasis in colorectal cancer.