CAJ | 학술논문

腺苷是一种内皮源性嘌呤核苷,通过与A1、A2A、A2B及A3四种腺苷受体亚型相结合而发挥不同的生物学效应.腺苷对于缺氧、术后和特发性等多种原因引起的肺动脉高压都具有明显的治疗效果,但其作用机制尚存在争议.本文综述了腺苷对肺动脉高压的作用机制及治疗研究进展.
선감시일충내피원성표령핵감,통과여A1、A2A、A2B급A3사충선감수체아형상결합이발휘불동적생물학효응.선감대우결양、술후화특발성등다충원인인기적폐동맥고압도구유명현적치료효과,단기작용궤제상존재쟁의.본문종술료선감대폐동맥고압적작용궤제급치료연구진전.
Adenosine is an endogenous nucleoside that mediates several important functions by the activation of four known cell surface (A1, A2A,A2B and A3) receptors. Adenosine therapy for the hypoxia, postoperative and other causes of pulmonary arterial hypertension has a significant effect,but its mechanisms are still controversial. This review describes the recent advances of adenosine in the study of mechanism and treatment of pulmonary arterial hypertension.