CAJ | 학술논문

随着儿童肥胖发病率的增加,儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的发病率也明显增加.肥胖已成为继腺样体和(或)扁桃体肥大后儿童OSAHS发病的第二大危险因素.儿童OSAHS和肥胖可能共同导致了代谢性疾病.OSAHS导致代谢异常可能与氧化应激、炎性反应和脂肪因子的释放有关.手术治疗是儿童OSAHS的首选治疗方法,而且能有效改善代谢异常,减少炎性反应因子的释放,改善血脂紊乱、呼吸暂停低通气指数和睡眠结构异常.
수착인동비반발병솔적증가,인동조새성수면호흡잠정저통기종합정(OSAHS)적발병솔야명현증가.비반이성위계선양체화(혹)편도체비대후인동OSAHS발병적제이대위험인소.인동OSAHS화비반가능공동도치료대사성질병.OSAHS도치대사이상가능여양화응격、염성반응화지방인자적석방유관.수술치료시인동OSAHS적수선치료방법,이차능유효개선대사이상,감소염성반응인자적석방,개선혈지문란、호흡잠정저통기지수화수면결구이상.
Along with the increasing prevalence of obesity in children,the prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) in children increased rapidly.Obesity has become the second largest risk factor of OSAHS following adenotonsillar hypertrophy in children.OSAHS and obesity together can lead to metabolic disease in children.Oxidative stress,inflammation and release of adipokines are thought to be linked to the metabolic abnormalitis as a consequence of OSAHS.Surgical treatment is the preferable treatment of OSAHS in children,which also can effectively improve the abnormal metabolic function,reduce levels of inflammatory markers,improve lipid profile,the apnea-hypopnea index and sleep fragmentation.