中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
10期
916-918
,共3页
陈方斌%金梅%徐乐平%周菲菲%汪莉%纪菊英
陳方斌%金梅%徐樂平%週菲菲%汪莉%紀菊英
진방빈%금매%서악평%주비비%왕리%기국영
迟发性运动障碍%精神分裂症%脑%铁%磁共振成像
遲髮性運動障礙%精神分裂癥%腦%鐵%磁共振成像
지발성운동장애%정신분렬증%뇌%철%자공진성상
Tardive dyskinesia%Schizophrenia%Brain%Iron%Magnetic resonance imaging
目的 探讨脑铁沉积与迟发性运动障碍(TD)的关系.方法 利用磁敏感加权成像技术,测定伴TD(TD组,n=18)、不伴TD(非TD组,n=18)的精神分裂症患者基底节灰质核团的校正相位值(CP)；采用异常不自主运动量表(AIMS)评定TD症状.结果 (1)调整年龄、性别、药物因素后,TD组黑质、尾状核CP值[分别(-0.194±0.040)rad,(-0.089±0.023)md]低于非TD组[分别(-0.163±0.033) rad,(-0.076 ±0.013)rad；P=0.022,0.023]；(2)TD组尾状核CP值与AIMS严重程度评分负相关(r=-0.486,P=0.034)；Logistic回归显示,黑质、尾状核CP值低(分别β=-72.12,- 156.43；P=0.029,0.037)、年龄高(β=0.370,P=0.042)与TD的发生有关.结论 TD患者基底节有脑铁过量沉积,并可能与TD的发生有关.
目的 探討腦鐵沉積與遲髮性運動障礙(TD)的關繫.方法 利用磁敏感加權成像技術,測定伴TD(TD組,n=18)、不伴TD(非TD組,n=18)的精神分裂癥患者基底節灰質覈糰的校正相位值(CP)；採用異常不自主運動量錶(AIMS)評定TD癥狀.結果 (1)調整年齡、性彆、藥物因素後,TD組黑質、尾狀覈CP值[分彆(-0.194±0.040)rad,(-0.089±0.023)md]低于非TD組[分彆(-0.163±0.033) rad,(-0.076 ±0.013)rad；P=0.022,0.023]；(2)TD組尾狀覈CP值與AIMS嚴重程度評分負相關(r=-0.486,P=0.034)；Logistic迴歸顯示,黑質、尾狀覈CP值低(分彆β=-72.12,- 156.43；P=0.029,0.037)、年齡高(β=0.370,P=0.042)與TD的髮生有關.結論 TD患者基底節有腦鐵過量沉積,併可能與TD的髮生有關.
목적 탐토뇌철침적여지발성운동장애(TD)적관계.방법 이용자민감가권성상기술,측정반TD(TD조,n=18)、불반TD(비TD조,n=18)적정신분렬증환자기저절회질핵단적교정상위치(CP)；채용이상불자주운동량표(AIMS)평정TD증상.결과 (1)조정년령、성별、약물인소후,TD조흑질、미상핵CP치[분별(-0.194±0.040)rad,(-0.089±0.023)md]저우비TD조[분별(-0.163±0.033) rad,(-0.076 ±0.013)rad；P=0.022,0.023]；(2)TD조미상핵CP치여AIMS엄중정도평분부상관(r=-0.486,P=0.034)；Logistic회귀현시,흑질、미상핵CP치저(분별β=-72.12,- 156.43；P=0.029,0.037)、년령고(β=0.370,P=0.042)여TD적발생유관.결론 TD환자기저절유뇌철과량침적,병가능여TD적발생유관.
Objective To explore the relationship between brain iron deposition and pathogenesis of tardive dyskinesia (TD) in schizophrenia.Methods The corrected phase (CP) of basal ganglia was measured in schizophrenia with TD( n=18) and without TD( n =18 ) using susceptibility weighted imaging MRI.Abnormal Involuntary Movement Scale (AIMS) was applied for clinical assessment of TD.Results After adjusting for age,sexual,and antipsychotic dosage,the mean CP of substantia nigra (SN) and caudate nucleus (CN) were significantly lower in schizophrenia patients with TD ( ( - 0.194 ± 0.040 ) rad,( - 0.089 ± 0.023 ) rad) than those without TD ( ( - 0.163 ± 0.033 ) rad,( - 0.076 ± 0.013 ) rad ; P =0.022,0.023 ).Lower mean CP in CN correlated with higher severity score of AIMS in TD patients ( r =- 0.468,P =0.034).Logistic regression analysis showed that the lower CP vaule in SN (β=-72.12,P=0.029) and CN(β=- 156.43,P=0.037),aging (β=0.379,P=0.042)were associated with the onset of TD.Conclusion The results imply that the excess iron accumulation in basal ganglia may be associated with pathogenesis of TD in schizophrenia.
