CAJ | 학술논문

目的探讨接触性热痛诱发电位早期诊断糖尿病周围神经病的价值.方法糖尿病患者75例根据神经传导检测正常与否分为糖尿病神经传导正常组与糖尿病神经传导异常组,采用Medoc分析仪,测定不同温度强度刺激时75例糖尿病患者和33例正常对照者不同温度强度刺激下的接触性热痛诱发电位(CHEP)潜伏期,进行比较分析.结果糖尿病神经传导正常组与正常对照组45℃ N1、45℃P1、50℃NI、53℃N1、53℃P1CHEP潜伏期的差异有统计学意义(P<0.05),尤其中等和较高温度刺激更加敏感;糖尿病患者CHEP潜伏期与多伦多评分值正相关.结论接触性热痛诱发电位可以比常规神经传导检测更早发现糖尿病周围神经的损害;糖尿病组CHEP潜伏期的延长程度与患者的临床状况明显相关.
목적 탐토접촉성열통유발전위조기진단당뇨병주위신경병적개치.방법 당뇨병환자75례근거신경전도검측정상여부분위당뇨병신경전도정상조여당뇨병신경전도이상조,채용Medoc분석의,측정불동온도강도자격시75례당뇨병환자화33례정상대조자불동온도강도자격하적접촉성열통유발전위(CHEP)잠복기,진행비교분석.결과 당뇨병신경전도정상조여정상대조조45℃ N1、45℃P1、50℃NI、53℃N1、53℃P1CHEP잠복기적차이유통계학의의(P<0.05),우기중등화교고온도자격경가민감;당뇨병환자CHEP잠복기여다륜다평분치정상관.결론 접촉성열통유발전위가이비상규신경전도검측경조발현당뇨병주위신경적손해;당뇨병조CHEP잠복기적연장정도여환자적림상상황명현상관.
Objective To study the value of contact heat evoked potentials (CHEPs) for the early diagnosis of diabetic peripheral polyneuropathy. Methods Seventy-five diabetic patients were examined by conventional nerve conduction velocity studies and then divided into 2 groups: diabetics with normal nerve conduction and diabetics with abnormal nerve conduction. Thirty-three normal subjects were used as controls. Toronto Clinical Neuropathy Sco-ring System was used to evaluate the patients. CHEPs were recorded using different stimulation intensities at different temperatures. Results The peak latencies of 45℃ , 50℃, 53℃ in diabetics with normal nerve conduction group were longer than those in normal control group, with a significant difference between the 2 groups(P<0.05). The peak latencies of diabetics were positively related to Toronto scores. Conclusion CHEPs could detect the impair-ment of diabetic peripheral nerve and reveal the impairment earlier than conventional nerve conduction velocity exami-nation, The prolongation of peak latency in diabetics group was significantly and positively related to clinical condi-tion.