CAJ | 학술논문

目的观察人胃癌S100A4和血管内皮生长因子(VEGF)-C、VEGF-D的表达,探讨其与临床病理特征及预后的关系.方法应用免疫组织化学方法检测108例人胃癌及20例癌旁组织中S100A4和VEGF-C、VEGF-D的表达.分析S100A4和VEGF-C、VEGF-D表达与患者年龄、性别、肿瘤大小、病理类型、浸润深度、淋巴结转移和肿瘤TNM分期的关系,并作预后分析.结果 S100A4和VEGF-C、VEGF-D在胃癌组织中的阳性率明显高于癌旁组织(P＜0.05).S100A4的表达与肿瘤大小和淋巴结转移有关(P＜0.05),VEGF-C的表达与淋巴结转移和TNM分期有关(P＜0.05),VEGF-D的表达与淋巴结转移和TNM分期无明显相关(P＞0.05),肿瘤组织内S100A4和VEGF-C两者表达呈正相关(P＜0.05).S100A4和VEGF-C、VEGF-D阳性胃癌患者5年生存率分别低于阴性患者,差异无统计学意义(P＞0.05).结论 S100A4和VEGF-C的表达与胃癌的淋巴结转移有关,S100A4可能参与VEGF-C淋巴管生成通路,在胃癌的淋巴结转移中发挥重要作用.
목적 관찰인위암S100A4화혈관내피생장인자(VEGF)-C、VEGF-D적표체,탐토기여림상병리특정급예후적관계.방법 응용면역조직화학방법검측108례인위암급20례암방조직중S100A4화VEGF-C、VEGF-D적표체.분석S100A4화VEGF-C、VEGF-D표체여환자년령、성별、종류대소、병리류형、침윤심도、림파결전이화종류TNM분기적관계,병작예후분석.결과 S100A4화VEGF-C、VEGF-D재위암조직중적양성솔명현고우암방조직(P＜0.05).S100A4적표체여종류대소화림파결전이유관(P＜0.05),VEGF-C적표체여림파결전이화TNM분기유관(P＜0.05),VEGF-D적표체여림파결전이화TNM분기무명현상관(P＞0.05),종류조직내S100A4화VEGF-C량자표체정정상관(P＜0.05).S100A4화VEGF-C、VEGF-D양성위암환자5년생존솔분별저우음성환자,차이무통계학의의(P＞0.05).결론 S100A4화VEGF-C적표체여위암적림파결전이유관,S100A4가능삼여VEGF-C림파관생성통로,재위암적림파결전이중발휘중요작용.
Objective To research the expression of S100A4 and vascular endothelial growth factor (VEGF) C and D in gastric carcinoma and there correlation with clinicopathological features and prognosis.Methods S100A4,VEGF-C and VEGF-D proteins were measured in 108 gastric carcinoma specimens and 20 specimens in adjacent carcinoma tissue by using immunohistochemistry.The correlations between the expression of S100A4,VEGF-C and VEGF-D with patients' age,gender,the tumor size,pathological differentiation,invasion depth,TNM stage and prognosis were evaluated.Results The expression levels of S100A4,VEGF-C and VEGF-D in gastric carcinoma were significantly higher than those in adjacent carcinoma tissues (P ＜ 0.05 ).The expression of S100A4 was associated with the tumor size and lymph node metastasis (P ＜ 0.05),and that of VEGF-C was associated with lymph node metastasis and clinical TNM stage (P ＜ 0.05),but that of VEGF-D was not associated with lymph node metastasis and clinical TNM stage ( P ＞ 0.05 ).S100A4 was positively correlated with VEGF-C in carcinoma tissues ( P ＜0.05).Five-year survival rate of carcinoma patients with positive expression of S100A4,VEGF-C and VEGF-D was lower than that of negative cases,but there were no statistically significant differences ( P ＞0.05).Conclusion The expression of S100A4 and VEGF-C is associated wtih lymph node metastasis.The expression of VEGF-C is associated with the pathway of lymphangiogenesis and may play an important role in lymph node metastasis in gastric carcinoma.