新疆博尔塔拉蒙古自治州哈萨克族胰岛素受体底物-1基因G972R多态性与原发性高血压关联
신강박이탑랍몽고자치주합살극족이도소수체저물-1기인G972R다태성여원발성고혈압관련
Association of the G972R polymorphism of IRS-1 with essential hypertension in Xinjiang kazakh group
  • 万方数据
    现代保健·医学创新研究 현대보건·의학창신연구
    MODERN HEALTH·MEDICINE INNOVATION RESEARCH
    2006年 5期 3-5 ,共3页

    赵蕾%徐翀%敖由特%王坤%郭艳英%宋涛%格尔莉%武贵臻%陈艳%何秉贤

    조뢰%서충%오유특%왕곤%곽염영%송도%격이리%무귀진%진염%하병현

    哈萨克族%高血压病%胰岛素受体底物-1%基因%基因多态性 哈薩剋族%高血壓病%胰島素受體底物-1%基因%基因多態性
    합살극족%고혈압병%이도소수체저물-1%기인%기인다태성
    目的 研究哈萨克族胰岛素受体底物-1(IRS-1)G972R多态性同原发性高血压的关系.方法 抽取哈萨克族原发性高血压及正常对照测定身高、体重、收缩压、舒张压、空腹血糖、血浆胆固醇、甘油三脂.提取DNA,链式反应-限制性片段长度多态性(PCR-RFLP)技术测定IRS-1基因G972R多态性.结果 哈萨克族原发性高血压和正常人群IRS-1 G972R多态GR,GR基因型频率之间差异无显著性(0.97,0.04及0.97,0.03,X2＝0.240,P＞0.05);两组中G及R等位基因频率差异无显著性(0.98,0.02及0.99,0.01,P＞0.05).未发现GG,GR基因型间体重指数、血糖及血脂水平有显著性差异.结论 IRS-1基因G972R多态性可能与新疆博尔塔拉蒙古自治州哈萨克族原发性高血压无关.
    목적 연구합살극족이도소수체저물-1(IRS-1)G972R다태성동원발성고혈압적관계.방법 추취합살극족원발성고혈압급정상대조측정신고、체중、수축압、서장압、공복혈당、혈장담고순、감유삼지.제취DNA,련식반응-한제성편단장도다태성(PCR-RFLP)기술측정IRS-1기인G972R다태성.결과 합살극족원발성고혈압화정상인군IRS-1 G972R다태GR,GR기인형빈솔지간차이무현저성(0.97,0.04급0.97,0.03,X2＝0.240,P＞0.05);량조중G급R등위기인빈솔차이무현저성(0.98,0.02급0.99,0.01,P＞0.05).미발현GG,GR기인형간체중지수、혈당급혈지수평유현저성차이.결론 IRS-1기인G972R다태성가능여신강박이탑랍몽고자치주합살극족원발성고혈압무관.
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