CAJ | 학술논문

背景：多孔钽金属具有整体容积孔隙率高、弹性模量低及表面摩擦系数高等特点，以其稳定的生物学特性、良好的生物相容性和特有的结构性质，引起医学界特别是骨科领域的广泛关注。 　　目的：综述钽金属的生物学特性，包括其机械性能、生物相容性及生物活性。 　　方法：应用计算机检索1990至2014年PubMed数据库、中文科技期刊数据库、万方数据库、维普数据库中有关多孔钽金属的文献。英文检索词为“Porous tantalum，biological character，orthopedic applications”，中文检索词为“多孔钽；生物学特性；骨科应用”。 　　结果与结论：多孔钽金属具有较大的孔隙率与表面摩擦力，有与人体骨质接近的弹性模量，有较好的生物相容性，其作为良好的骨科植入材料越来越被大家所接受，目前多应用于一体化髋臼杯、全髋关节翻修臼杯与髋臼增强垫块、多孔钽金属棒及胫骨平台假体、髌骨假体等的制备中。骨外科中应用多种多孔钽金属植入体的短期随访已有报道，临床数据、放射学检查及取出物的组织学分析已证明该材料的实用性和安全性，但该材料的远期效果如何还有待证实。
배경：다공단금속구유정체용적공극솔고、탄성모량저급표면마찰계수고등특점，이기은정적생물학특성、량호적생물상용성화특유적결구성질，인기의학계특별시골과영역적엄범관주。 　　목적：종술단금속적생물학특성，포괄기궤계성능、생물상용성급생물활성。 　　방법：응용계산궤검색1990지2014년PubMed수거고、중문과기기간수거고、만방수거고、유보수거고중유관다공단금속적문헌。영문검색사위“Porous tantalum，biological character，orthopedic applications”，중문검색사위“다공단；생물학특성；골과응용”。 　　결과여결론：다공단금속구유교대적공극솔여표면마찰력，유여인체골질접근적탄성모량，유교호적생물상용성，기작위량호적골과식입재료월래월피대가소접수，목전다응용우일체화관구배、전관관절번수구배여관구증강점괴、다공단금속봉급경골평태가체、빈골가체등적제비중。골외과중응용다충다공단금속식입체적단기수방이유보도，림상수거、방사학검사급취출물적조직학분석이증명해재료적실용성화안전성，단해재료적원기효과여하환유대증실。
BACKGROUND:Porous tantalum, characterized as high porosity, low elastic modulus, high friction coefficient, stable biological properties, good compatibility and typical structural properties, has been the focus in medicine, especial y in orthopedics. OBJECTIVE:To review the biological characteristics of porous tantalum, including its mechanical properties, compatibility, and biological activity. METHODS:A computer-based search of PubMed, CSTJ, Wanfang and VIP databases was done for articles relevant to porous tantalum published from 1990 to 2014 using the keywords of“porous tantalum, biological character, orthopedic applications”both in English and Chinese. RESULTS AND CONCLUSION:Porous tantalum, with high porosity, low elastic modulus, high friction coefficient, and good compatibility, has become increasingly popular in medicine, especial y in orthopedics. At present, porous tantalum is used in the preparation of the integrated acetabular cup, total hip arthroplasty acetabular cup, acetabular reinforcing pad, porous tantalum metal rod, tibial plateau prosthesis and patel ar prosthesis and tibial plateau prosthesis. The short-term fol ow-up of porous tantalum implants in orthopedic surgery has been reported. And clinical data, radiology, histological analysis of the removed material have proved the practicability and safety of the porous tantalum. But the long-term effects of porous tantalum remain to be confirmed.