CAJ | 학술논문

旨在探讨金黄色葡萄球菌肠毒素A(SEA)在KM鼠体内的抑瘤效果.建立H22荷瘤小鼠模型,将20只小鼠随机分为对照组(生理盐水)、低剂量组(15 μg/ml)、中剂量组(25 μg/ml)和高剂量组(50 μg/ml),观察肿瘤生长趋势,计算抑瘤率,通过ELISA检测IL-2的含量.结果显示,给药组肿瘤生长趋势均较对照组缓慢;对照组、低剂量组、中剂量组、高剂量组的抑瘤率分别为0,28.9%,34.0%,51.0%(P<0.05);血清中IL-2含量分别为58.9 pg/ml、83.6 pg/ml、91.8 pg/ml、118.1 pg/ml.金黄色葡萄球菌肠毒素A(SEA)可抑制H22肿瘤的生长,并上调IL-2的分泌.
지재탐토금황색포도구균장독소A(SEA)재KM서체내적억류효과.건립H22하류소서모형,장20지소서수궤분위대조조(생리염수)、저제량조(15 μg/ml)、중제량조(25 μg/ml)화고제량조(50 μg/ml),관찰종류생장추세,계산억류솔,통과ELISA검측IL-2적함량.결과현시,급약조종류생장추세균교대조조완만;대조조、저제량조、중제량조、고제량조적억류솔분별위0,28.9%,34.0%,51.0%(P<0.05);혈청중IL-2함량분별위58.9 pg/ml、83.6 pg/ml、91.8 pg/ml、118.1 pg/ml.금황색포도구균장독소A(SEA)가억제H22종류적생장,병상조IL-2적분비.
It was to study inhibition effect of staphylococcal enterotoxin A(SEA)on H22 solid tumors in KM mice.A total of 30 cases of S180 mice were randomly assigned into 4 groups,control(saline),low doses(15 μg/ml),middle doses(25 μg/ml),and high doses(50 μg/ml).The inhibition ratio of tumor growth and value of IL-2 in serum were studied respectively.Results showed that compared to the control group,the tumor growth of the treatment groups was slowly.The tumor-inhibition ratios of control,low doses,middle doses,and high doses were 0,34.0%,28.9% and 51.0%(P<0.05)and the values of IL-2 were 58.9 pg/ml,83.6 pg/ml,91.8 pg/ml,and 118.1pg/ml.Therefore,these results suggest that SEA can inhibit the growth of H22 solid tumors in vivo,and increase the secretion of IL-2.