CAJ | 학술논문

目的:研究唑来膦酸和伊班膦酸钠治疗恶性肿瘤骨转移疼痛的药物经济学.方法:45例恶性肿瘤骨转移疼痛的患者随机分为两组,一组接受4mg唑来膦酸治疗,另一组接受4mg伊班膦酸钠治疗,比较两组患者首次住院双膦酸盐治疗的总费用、费用组成、疼痛缓解率、不良反应,进行药物经济学的费用-效果分析.结果:唑来膦酸组(n=23 )总费用低于伊班膦酸钠组(n= 22),分别为2 409.22元和3 903.64元(P<0.05);两组疼痛缓解有效率分别为78.3%和72.3%,无显著性差异 (P>0.05);两组费用-效果比为31.75和53.99;不良反应发生率两组间无显著性差异(P>0.05).结论:唑来膦酸是治疗恶性肿瘤骨转移的安全、有效、经济的药物.
목적:연구서래련산화이반련산납치료악성종류골전이동통적약물경제학.방법:45례악성종류골전이동통적환자수궤분위량조,일조접수4mg서래련산치료,령일조접수4mg이반련산납치료,비교량조환자수차주원쌍련산염치료적총비용、비용조성、동통완해솔、불량반응,진행약물경제학적비용-효과분석.결과:서래련산조(n=23 )총비용저우이반련산납조(n= 22),분별위2 409.22원화3 903.64원(P<0.05);량조동통완해유효솔분별위78.3%화72.3%,무현저성차이 (P>0.05);량조비용-효과비위31.75화53.99;불량반응발생솔량조간무현저성차이(P>0.05).결론:서래련산시치료악성종류골전이적안전、유효、경제적약물.
Objective:To evaluate the pharmacoeconomics of zoledronate in treatment of metastatic bone pain of malignancy,compared with ibandronate.Methods:Total of 45 patients with metastatic bone pain of malignancy were randomly divided into two groups to receive 4 mg zoledronate or 4 mg ibandronate.Total cost,cost composition,pain relief response rate and side effects in the first treatment cycle were assessed.A cost-benefit analysis was conducted.Results: The total cost of zoledronate group (n=23) and ibandronate group (n=22) was 2409.22 yuan and 3903.64 yuan respectively (P<0.05).The pain relief rate was 78.3% and 72.3% respectively (P>0.05).The cost / effect of zoledronate group was lower than that of ibandronate group (31.75 vs 53.99).There were no significant differences in incidence of adverse reactions (P>0.05).Conclusion:Zoledronate is a safe,efficient and economic alternative in the treatment of metastatic bone pain of malignancy.