中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
43期
7023-7027
,共5页
生物材料%材料相容性%支架置入%Wal stent支架%颅外颈动脉狭窄%经皮血管成形
生物材料%材料相容性%支架置入%Wal stent支架%顱外頸動脈狹窄%經皮血管成形
생물재료%재료상용성%지가치입%Wal stent지가%로외경동맥협착%경피혈관성형
背景：颈动脉支架置入是一种微创、安全、简便的介入治疗方法，对于身体基础状况差不能耐受开放手术的颈动脉狭窄患者尤其有意义。<br> 目的：探讨支架置入联合经皮血管成形治疗颅外颈动脉狭窄的临床效果。<br> 方法：纳入颅外颈动脉狭窄患者29例，其中男19例，女10例，年龄45-78岁，进行支架置入及经皮血管成形治疗，治疗前及治疗后24 h进行美国国立卫生研究院卒中量表量表、神经功能评分及CT检查；随访3-12个月，复查凝血指标及颈动脉B超。<br> 结果与结论：1例患者为右侧颈总动脉分叉部完全闭塞，经治疗仅颈外动脉管径恢复50.0%，其余患者均经血管造影证实完全恢复至正常水平，治疗成功率为97%。29例患者治疗后24 h的颈动脉病变血管长度、美国国立卫生研究院卒中量表量表、神经功能评分均较治疗前明显改善(P<0.01，P<0.05)。随访3-12个月，所有患者均未出现脑梗死和短暂脑缺血发作，颈动脉狭窄明显改善，6个月复查时患者出现再狭窄，再狭窄率为3%。表明经皮血管成形联合生物材料支架置入治疗颅外颈动脉狭窄可以获得良好的临床效果。
揹景：頸動脈支架置入是一種微創、安全、簡便的介入治療方法，對于身體基礎狀況差不能耐受開放手術的頸動脈狹窄患者尤其有意義。<br> 目的：探討支架置入聯閤經皮血管成形治療顱外頸動脈狹窄的臨床效果。<br> 方法：納入顱外頸動脈狹窄患者29例，其中男19例，女10例，年齡45-78歲，進行支架置入及經皮血管成形治療，治療前及治療後24 h進行美國國立衛生研究院卒中量錶量錶、神經功能評分及CT檢查；隨訪3-12箇月，複查凝血指標及頸動脈B超。<br> 結果與結論：1例患者為右側頸總動脈分扠部完全閉塞，經治療僅頸外動脈管徑恢複50.0%，其餘患者均經血管造影證實完全恢複至正常水平，治療成功率為97%。29例患者治療後24 h的頸動脈病變血管長度、美國國立衛生研究院卒中量錶量錶、神經功能評分均較治療前明顯改善(P<0.01，P<0.05)。隨訪3-12箇月，所有患者均未齣現腦梗死和短暫腦缺血髮作，頸動脈狹窄明顯改善，6箇月複查時患者齣現再狹窄，再狹窄率為3%。錶明經皮血管成形聯閤生物材料支架置入治療顱外頸動脈狹窄可以穫得良好的臨床效果。
배경：경동맥지가치입시일충미창、안전、간편적개입치료방법，대우신체기출상황차불능내수개방수술적경동맥협착환자우기유의의。<br> 목적：탐토지가치입연합경피혈관성형치료로외경동맥협착적림상효과。<br> 방법：납입로외경동맥협착환자29례，기중남19례，녀10례，년령45-78세，진행지가치입급경피혈관성형치료，치료전급치료후24 h진행미국국립위생연구원졸중량표량표、신경공능평분급CT검사；수방3-12개월，복사응혈지표급경동맥B초。<br> 결과여결론：1례환자위우측경총동맥분차부완전폐새，경치료부경외동맥관경회복50.0%，기여환자균경혈관조영증실완전회복지정상수평，치료성공솔위97%。29례환자치료후24 h적경동맥병변혈관장도、미국국립위생연구원졸중량표량표、신경공능평분균교치료전명현개선(P<0.01，P<0.05)。수방3-12개월，소유환자균미출현뇌경사화단잠뇌결혈발작，경동맥협착명현개선，6개월복사시환자출현재협착，재협착솔위3%。표명경피혈관성형연합생물재료지가치입치료로외경동맥협착가이획득량호적림상효과。
BACKGROUND:Carotid artery stenting is a minimal y invasive, safe, simple intervention, which is particularly meaningful to patients with carotid artery stenosis who exhibit poor physical basis and cannot tolerate open surgery. <br> OBJECTIVE:To explore the clinical effect of percutaneous transluminal angioplasty and stenting for treatment of extracranial carotid artery stenosis. <br> METHODS:Twenty-nine patients with extracranial carotid artery stenosis, including 19 males and 10 females, age ranging from 45-78 years, were enrol ed and subjected to stenting and percutaneous angioplasty. American National Institutes of Health Stroke Scale, modified Rankin Scale and CT examination were tested before treatment and 24 hours after treatment. After 3-12 months fol ow-up, the coagulation indexes and B ultrasound of the carotid artery were reviewed. <br> RESULTS AND CONCLUSION:One patient exhibited the complete bifurcation occlusion of the right common carotid artery, and only the diameter of external carotid artery recovered 50.0%. The remaining patients were confirmed by angiograph that completely restored to normal levels, and the success rate was 97%. At 24 hours after treatment, al the 29 patients exhibit significant improvement in the diameter of lesioned carotid artery, scores on American National Institutes of Health Stroke Scale and modified Rankin Scale (P<0.01, P<0.05). During the 3-12 months fol ow-up, no cerebral infarction and transient cerebral ischemia occurred and carotid artery stenosis was improved in al patients. At 6 months after operation, one patient had restenosis, and the restenosis rate was 3%. Percutaneous angioplasty combined with biological material stenting for treatment of extracranial carotid artery stenosis can obtain good clinical effects.
