中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
7期
685-688
,共4页
多潘立酮%功能性消化不良%胃电图
多潘立酮%功能性消化不良%胃電圖
다반립동%공능성소화불량%위전도
Domperidone%Functional dyspepsia%Electrogastrogram
目的 研究多潘立酮对功能性消化不良(FD)患者的治疗效果,进一步探讨其治疗机制.方法 采用自身对照的研究方法,随机选取31例FD患者,停止应用影响胃酸分泌及胃动力的药物1周后,给予症状评分,并进行胃排空检测和餐前、餐后胃电图的检测;口服多潘立酮2周后,再次进行症状评分,并进行胃排空和餐前、餐后胃电图检测.结果 FD患者口服多潘立酮2周后,上腹痛、腹胀、早饱、嗳气等临床症状明显改善,治疗前症状积分48.20±21.71,治疗后症状积分19.00±11.03,治疗前后比较,差异有统计学意义(P<0.01);FD 患者治疗前后胃排空率检测比较:2、5 h胃总排空率均明显增加(17%与57%,56%与96%,均P<0.01);FD患者治疗后与治疗前胃电参数指标进行比较:①主频:实验组治疗前餐前主频值(2.57±0.60)cpm,餐后主频值(2.70±0.53)cpm;治疗后餐前主频值(3.00±0.26)cpm,餐后主频值(3.01±0.27)cpm;FD患者口服多潘立酮两周后主频与治疗前比较,餐前之间相比差异有统计学意义(P<0.05),餐后之间相比差异亦有统计学意义(P<0.05).②主功率:实验组治疗前餐前主功率值(55.36±8.46)μV,餐后(72.30±10.35)μV;实验组治疗后餐前主功率值(75.06±13.13)μV,餐后(112.27±17.27)μV,主功率显著增加(P<0.05);③正常胃电慢波百分比显著增多(54.8%→93.4%)(P<0.01);胃动过缓百分比显著减少(19.4%→3.2%)(P<0.01);胃动过速百分比显著减少(25.8%→3.2%)(P<0.01).结论 多潘立酮可显著改善FD患者的上腹痛、腹胀、早饱、嗳气等主要症状,增强胃电活动及胃排空,增加胃电可见图的主频及主功率,使紊乱的胃电节律趋于正常.
目的 研究多潘立酮對功能性消化不良(FD)患者的治療效果,進一步探討其治療機製.方法 採用自身對照的研究方法,隨機選取31例FD患者,停止應用影響胃痠分泌及胃動力的藥物1週後,給予癥狀評分,併進行胃排空檢測和餐前、餐後胃電圖的檢測;口服多潘立酮2週後,再次進行癥狀評分,併進行胃排空和餐前、餐後胃電圖檢測.結果 FD患者口服多潘立酮2週後,上腹痛、腹脹、早飽、噯氣等臨床癥狀明顯改善,治療前癥狀積分48.20±21.71,治療後癥狀積分19.00±11.03,治療前後比較,差異有統計學意義(P<0.01);FD 患者治療前後胃排空率檢測比較:2、5 h胃總排空率均明顯增加(17%與57%,56%與96%,均P<0.01);FD患者治療後與治療前胃電參數指標進行比較:①主頻:實驗組治療前餐前主頻值(2.57±0.60)cpm,餐後主頻值(2.70±0.53)cpm;治療後餐前主頻值(3.00±0.26)cpm,餐後主頻值(3.01±0.27)cpm;FD患者口服多潘立酮兩週後主頻與治療前比較,餐前之間相比差異有統計學意義(P<0.05),餐後之間相比差異亦有統計學意義(P<0.05).②主功率:實驗組治療前餐前主功率值(55.36±8.46)μV,餐後(72.30±10.35)μV;實驗組治療後餐前主功率值(75.06±13.13)μV,餐後(112.27±17.27)μV,主功率顯著增加(P<0.05);③正常胃電慢波百分比顯著增多(54.8%→93.4%)(P<0.01);胃動過緩百分比顯著減少(19.4%→3.2%)(P<0.01);胃動過速百分比顯著減少(25.8%→3.2%)(P<0.01).結論 多潘立酮可顯著改善FD患者的上腹痛、腹脹、早飽、噯氣等主要癥狀,增彊胃電活動及胃排空,增加胃電可見圖的主頻及主功率,使紊亂的胃電節律趨于正常.
목적 연구다반립동대공능성소화불량(FD)환자적치료효과,진일보탐토기치료궤제.방법 채용자신대조적연구방법,수궤선취31례FD환자,정지응용영향위산분비급위동력적약물1주후,급여증상평분,병진행위배공검측화찬전、찬후위전도적검측;구복다반립동2주후,재차진행증상평분,병진행위배공화찬전、찬후위전도검측.결과 FD환자구복다반립동2주후,상복통、복창、조포、애기등림상증상명현개선,치료전증상적분48.20±21.71,치료후증상적분19.00±11.03,치료전후비교,차이유통계학의의(P<0.01);FD 환자치료전후위배공솔검측비교:2、5 h위총배공솔균명현증가(17%여57%,56%여96%,균P<0.01);FD환자치료후여치료전위전삼수지표진행비교:①주빈:실험조치료전찬전주빈치(2.57±0.60)cpm,찬후주빈치(2.70±0.53)cpm;치료후찬전주빈치(3.00±0.26)cpm,찬후주빈치(3.01±0.27)cpm;FD환자구복다반립동량주후주빈여치료전비교,찬전지간상비차이유통계학의의(P<0.05),찬후지간상비차이역유통계학의의(P<0.05).②주공솔:실험조치료전찬전주공솔치(55.36±8.46)μV,찬후(72.30±10.35)μV;실험조치료후찬전주공솔치(75.06±13.13)μV,찬후(112.27±17.27)μV,주공솔현저증가(P<0.05);③정상위전만파백분비현저증다(54.8%→93.4%)(P<0.01);위동과완백분비현저감소(19.4%→3.2%)(P<0.01);위동과속백분비현저감소(25.8%→3.2%)(P<0.01).결론 다반립동가현저개선FD환자적상복통、복창、조포、애기등주요증상,증강위전활동급위배공,증가위전가견도적주빈급주공솔,사문란적위전절률추우정상.
Objective To investigate the curative effect of Domperidone in treating functional dyspepsia (FD),to observe the changes of electrogastmgram in these patients both before and after meal,and to investigate the mechanism of Dompefidone for treating FD.Methods Serf-control methods were used for study.31 patients with functional dyspepsia selected randomly committed to symptom score after they stopped taking medicine that affected gastric acid secretion for a week.Then the changes of eleetrogastrogram were detected before meal with emptying of stomach.After patients took orally Domperidone for two weeks,electrogastrogram and symptoms score were detected again under the same condition.Results 2 weeks after treatment with oral Domperidone,the patients had signifi- cant improvement in upper abdominal pain,abdominal distension and belching.The symptom 8core changed from 48.20±21.71 to 19.00±11.03(P<0.01).The gastric emptying rate for 2 hours and 5 hours increased signifi- cantly after treatment(P<0.01).As for the gastric electrical activity parameter:①basic frequency changed from (2.57±0.60)cpm to(3.00±0.26)cpm before meal,and changed from (2.70±0.53)cpm to(3.01±0.27) cpm(P<0.05 for each).②main power-experimental group's main power changed from(55.36±8.46)μV to (75.06±13.13)μV before treatment and meal.and changed from(72.30±10.35)μV to(112.27±17.27)μV after meal and treatment(P<0.05).③Slow wave of gastric electrical activity(N%)increased significantly (54.8%→93.4%)(P<0.01).Bradygastria(B%)reduced significantly(19.4%→3.2%)(P<0.01).Tachyg- astria(T%)reduced significantly(25.8%→3.2%)(P<0.01).Conclusion Dompefidone has significant effect in improving some major symptoms like upper abdominal pain,abdominal distension and belching-and may strength- en gastric emptying,increase basic frequency and main power of electrngastrngram,so to convert the disturbed gastric electrical activity to normal.
