中国行为医学科学
中國行為醫學科學
중국행위의학과학
2008年
8期
707-708
,共2页
翟杰%仇新华%王海琴%崔吉俊
翟傑%仇新華%王海琴%崔吉俊
적걸%구신화%왕해금%최길준
注意缺陷多动障碍%学习障碍%脑电生物反馈%β-内啡肽%脑源性神经营养因子
註意缺陷多動障礙%學習障礙%腦電生物反饋%β-內啡肽%腦源性神經營養因子
주의결함다동장애%학습장애%뇌전생물반궤%β-내배태%뇌원성신경영양인자
Attention deficit hyperactivity disorder%Leaming disorder%EEG biofeedback%β-Endorphin%BDNF
目的 探讨脑电生物反馈治疗对共患注意缺陷多动障碍(ADHD)和学习障碍患儿血清beta-内啡肽(β-EP)、脑源性神经营养因子(BDNF)影响.方法 应用Sprit-8脑电生物反馈治疗仪,对48例(6～12岁)共患ADHD和学习障碍儿童进行40次增强16～20 Hz β波,抑制4～8 Hz θ波脑电反馈治疗,采用脑电反馈仪检测患儿脑电波θ/β、θ/SMR功率比值的变化,采用酶联夹心免疫吸附测定法检测血清浓度.结果 脑电反馈治疗后患儿θ/β、θ/SMR值较前明显下降(P<0.01),血清β-EP浓度[(191.01±22.85)pg/ml]较前[(180.29 4-32.38)pg/ml]升高(t=3.86,P<0.01),血清BDNF浓度前后分别为(6.12±6.44)ng/ml,(4.40±3.68)ng/ml,差异无显著性(t=1.71,P>0.05).结论 β-EP可能在脑电生物反馈治疗共患ADHD和学习障碍机制中扮演蕈要角色.
目的 探討腦電生物反饋治療對共患註意缺陷多動障礙(ADHD)和學習障礙患兒血清beta-內啡肽(β-EP)、腦源性神經營養因子(BDNF)影響.方法 應用Sprit-8腦電生物反饋治療儀,對48例(6～12歲)共患ADHD和學習障礙兒童進行40次增彊16～20 Hz β波,抑製4～8 Hz θ波腦電反饋治療,採用腦電反饋儀檢測患兒腦電波θ/β、θ/SMR功率比值的變化,採用酶聯夾心免疫吸附測定法檢測血清濃度.結果 腦電反饋治療後患兒θ/β、θ/SMR值較前明顯下降(P<0.01),血清β-EP濃度[(191.01±22.85)pg/ml]較前[(180.29 4-32.38)pg/ml]升高(t=3.86,P<0.01),血清BDNF濃度前後分彆為(6.12±6.44)ng/ml,(4.40±3.68)ng/ml,差異無顯著性(t=1.71,P>0.05).結論 β-EP可能在腦電生物反饋治療共患ADHD和學習障礙機製中扮縯蕈要角色.
목적 탐토뇌전생물반궤치료대공환주의결함다동장애(ADHD)화학습장애환인혈청beta-내배태(β-EP)、뇌원성신경영양인자(BDNF)영향.방법 응용Sprit-8뇌전생물반궤치료의,대48례(6～12세)공환ADHD화학습장애인동진행40차증강16～20 Hz β파,억제4～8 Hz θ파뇌전반궤치료,채용뇌전반궤의검측환인뇌전파θ/β、θ/SMR공솔비치적변화,채용매련협심면역흡부측정법검측혈청농도.결과 뇌전반궤치료후환인θ/β、θ/SMR치교전명현하강(P<0.01),혈청β-EP농도[(191.01±22.85)pg/ml]교전[(180.29 4-32.38)pg/ml]승고(t=3.86,P<0.01),혈청BDNF농도전후분별위(6.12±6.44)ng/ml,(4.40±3.68)ng/ml,차이무현저성(t=1.71,P>0.05).결론 β-EP가능재뇌전생물반궤치료공환ADHD화학습장애궤제중분연심요각색.
Objective To investigate the effect of EEG biofeedback treatment on serum β-EP and BDNF of children with comorbidity of attention deficit hyperactivity disorder(ADHD)and learning disorder.Methods Forty-eight children(ages 6～12)with comorbidity of ADHD and learning disorder diagnosed according to ICD-10 received 40 sessions of EEG biofeedback treatment.Feedback was contigent on enhancing 16～20Hz beta activity and suppressing 4～8 Hz theta activity.Serum levels of β-endorphin and BDNF were measured by enzyme linked immunosorbent assay.Results After treatment significante decreases were observed in the EEG ratio of the theta/beta and theta/SMR(P＜0.01).The mean concentration of serum β-EP increased significantly [(180.29±32.38)pg/ml Vs(191.01±22.85)pg/ml,t=3.86,P＜0.01].The mean concentration of serum BDNF had no significant change[(6.12 ±6.44)ng/ml Vs(4.40±3.68)ng/ml,t=1.71,P＞0.05].Conclusion It seems that highly β-EP levels play a role in the EEG biofeedback treatment pathogenesis of comorbidity of ADHD and learning disorder
