中华航海医学与高气压医学杂志
中華航海醫學與高氣壓醫學雜誌
중화항해의학여고기압의학잡지
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
2009年
6期
328-331
,共4页
晕船%去甲肾上腺素%肾上腺素%5-羟色胺%大鼠
暈船%去甲腎上腺素%腎上腺素%5-羥色胺%大鼠
훈선%거갑신상선소%신상선소%5-간색알%대서
Motion sickness%Norepinephrine (NE)%Epinephrine (E)%5-HT%Rat
目的 了解由支链氨基酸和酪氨酸组成的复方制剂对模拟晕船后大鼠脑干单胺类递质的影响.方法 给大鼠饲料分别添加支链氨基酸和由酪氨酸和支链氨基酸组成的复合制剂喂养10 d,大鼠经模拟晕船刺激后,应用高效液相色谱法检测脑干单胺类递质含量的变化.结果 与空白组相比,大鼠模拟晕船刺激后,去甲肾上腺素(NE)和肾上腺素(E)含量降低,5-羟色胺(5-HT)的含量升高;与晕船组相比,给予支链氨基酸后,NE的含量无明显变化,E的含量升高,而5-HT的含量降低;给予支链氨基酸和酪氨酸的复方制剂后,脑干5-HT含量显著降低,NE和E的含量显著升高.结论 氨幕酸制剂可改变模拟晕船大鼠脑干单胺类递质的含量,并通过单胺类递质含量变化影响晕船后的脑体功能.
目的 瞭解由支鏈氨基痠和酪氨痠組成的複方製劑對模擬暈船後大鼠腦榦單胺類遞質的影響.方法 給大鼠飼料分彆添加支鏈氨基痠和由酪氨痠和支鏈氨基痠組成的複閤製劑餵養10 d,大鼠經模擬暈船刺激後,應用高效液相色譜法檢測腦榦單胺類遞質含量的變化.結果 與空白組相比,大鼠模擬暈船刺激後,去甲腎上腺素(NE)和腎上腺素(E)含量降低,5-羥色胺(5-HT)的含量升高;與暈船組相比,給予支鏈氨基痠後,NE的含量無明顯變化,E的含量升高,而5-HT的含量降低;給予支鏈氨基痠和酪氨痠的複方製劑後,腦榦5-HT含量顯著降低,NE和E的含量顯著升高.結論 氨幕痠製劑可改變模擬暈船大鼠腦榦單胺類遞質的含量,併通過單胺類遞質含量變化影響暈船後的腦體功能.
목적 료해유지련안기산화락안산조성적복방제제대모의훈선후대서뇌간단알류체질적영향.방법 급대서사료분별첨가지련안기산화유락안산화지련안기산조성적복합제제위양10 d,대서경모의훈선자격후,응용고효액상색보법검측뇌간단알류체질함량적변화.결과 여공백조상비,대서모의훈선자격후,거갑신상선소(NE)화신상선소(E)함량강저,5-간색알(5-HT)적함량승고;여훈선조상비,급여지련안기산후,NE적함량무명현변화,E적함량승고,이5-HT적함량강저;급여지련안기산화락안산적복방제제후,뇌간5-HT함량현저강저,NE화E적함량현저승고.결론 안막산제제가개변모의훈선대서뇌간단알류체질적함량,병통과단알류체질함량변화영향훈선후적뇌체공능.
Objective To investigate the effect of the fortified branch-chained amino acid (BCAA) and tyrosine (Tyr) on the monoamine in brain stem following motion stimulation. Methods Rats were fed with the compound preparation fortified with branch-chained amino acid and tyrosine for 10 days, and then contents of monoamine neurotransmitter in the rat brain stem were determined following motion stimulation. Results Following motion stimulation, norepinephrine (NE) and epinephrine (E) decreased, while 5-HT increased in the rat brain stem. When a comparison was made with the motion stimulation (MS) group, the content of NE in BCAA fortification group showed no significant change, whereas the content of E increased and 5-HT decreased. In the compound preparation group, the content of 5-HT was significantly lower, while NE and E were significantly higher than those of the MS group. Conclusions Preparation fortified with amino acids could influence changes in the contents of monoamine neurotransmitter in rat brain stem, which might be involved in the mental and physical functions of the animals during motion stimulation.
