国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
9期
1298-1301
,共4页
陈希曦%黎淑贞%邓爱民%崔媛媛%李冬梅%梁辉洪%戢开丽
陳希晞%黎淑貞%鄧愛民%崔媛媛%李鼕梅%樑輝洪%戢開麗
진희희%려숙정%산애민%최원원%리동매%량휘홍%집개려
体外受精-胚胎移植%短时受精
體外受精-胚胎移植%短時受精
체외수정-배태이식%단시수정
In vitro fertilization-embryo transfer%Short-time insemination
目的 探讨短时受精精卵共孵育时间对受精率的影响.方法 170例行体外受精-胚胎移植( IVF-ET)患者常规促排卵,依据精卵共孵育时间分为短时受精组(A组:57例,精卵共孵育2~3h;B组:58例,精卵共孵育4~5h)和常规受精组(C组:55例,精卵共孵育18 h );之后将卵子转移至新鲜培养基中.比较各组的受精率、卵裂率、优胚率、临床妊娠率、胚胎种植率.结果 三组受精率分别为63.01%、71.43%和78.72%,各组间的差异有统计学意义(P<0.05);C组的卵裂率、优胚率均低于A组和B组;C组与A组的卵裂率[97.05% vs 99.25%]、C组与B组的优胚率[37.14%vs 44.42%]之间的差异有统计学意义(P<0.05);各组间临床妊娠率、胚胎种植率差异无统计学意义(P> 0.05).结论 短时受精有助于提高卵裂率、优胚率,精卵共孵育时间4~5h的受精率较2~3h高.
目的 探討短時受精精卵共孵育時間對受精率的影響.方法 170例行體外受精-胚胎移植( IVF-ET)患者常規促排卵,依據精卵共孵育時間分為短時受精組(A組:57例,精卵共孵育2~3h;B組:58例,精卵共孵育4~5h)和常規受精組(C組:55例,精卵共孵育18 h );之後將卵子轉移至新鮮培養基中.比較各組的受精率、卵裂率、優胚率、臨床妊娠率、胚胎種植率.結果 三組受精率分彆為63.01%、71.43%和78.72%,各組間的差異有統計學意義(P<0.05);C組的卵裂率、優胚率均低于A組和B組;C組與A組的卵裂率[97.05% vs 99.25%]、C組與B組的優胚率[37.14%vs 44.42%]之間的差異有統計學意義(P<0.05);各組間臨床妊娠率、胚胎種植率差異無統計學意義(P> 0.05).結論 短時受精有助于提高卵裂率、優胚率,精卵共孵育時間4~5h的受精率較2~3h高.
목적 탐토단시수정정란공부육시간대수정솔적영향.방법 170례행체외수정-배태이식( IVF-ET)환자상규촉배란,의거정란공부육시간분위단시수정조(A조:57례,정란공부육2~3h;B조:58례,정란공부육4~5h)화상규수정조(C조:55례,정란공부육18 h );지후장란자전이지신선배양기중.비교각조적수정솔、란렬솔、우배솔、림상임신솔、배태충식솔.결과 삼조수정솔분별위63.01%、71.43%화78.72%,각조간적차이유통계학의의(P<0.05);C조적란렬솔、우배솔균저우A조화B조;C조여A조적란렬솔[97.05% vs 99.25%]、C조여B조적우배솔[37.14%vs 44.42%]지간적차이유통계학의의(P<0.05);각조간림상임신솔、배태충식솔차이무통계학의의(P> 0.05).결론 단시수정유조우제고란렬솔、우배솔,정란공부육시간4~5h적수정솔교2~3h고.
Objective To investigate effects of duration of sperm and egg co-incubation on the fertility rate in short time insemination.Methods 170 women undergoing in vitro fertilization - embryo transfer ( IVF-ET ) were divided into short-time insemination group ( group 1∶57 women,co-incubation for 2 h to 3 h; group 2:58 women,incubation for 4 h to 5 h ) and routine insemination group ( group 3∶55 women,co-incubation for 18 h ) based on duration of sperm and egg co-incubation.Then the oocytes were transferred to the fresh medium.The rates of fertility,cleavage,high-quality embryo,pregnancy, and implantation were compared among the groups.Results The fertility rate was 63.01%,71.43%,and 78.72% in each group,with a significant difference ( P< 0.05 ).The rates of cleavage and high-quality embryo were lower in group 3 than in groups 1 and 2.There were significant differences in the cleavage rate between group 3 and group 1 ( 97.05% vs.99.25% ) and in the high-quality embryo rate between group 3 and group 2 ( 37.14% vs.44.42% ) ( P< 0.05 ).There were no significant differences in the rates of pregnancy and implantation among the three groups ( P > 0.05 ).Conclusions Short-time insemination is beneficial for elevating the rates of the cleavage and high-quality embryo.The fertility rate of sperm and egg co-incubation for 4 h to 5 h is higher than that of co-incubation for 2 h to 3 h.