CAJ | 학술논문

目的探讨初诊2型糖尿病(T2DM)患者大血管病变(MD)的相关危险因素.方法将符合条件的232例初诊T2DM患者根据有无MD分为两组:MD组与非MD组,对两组患者的多项临床指标进行比较及相关分析.结果 (1)232例患者中,合并MD者95例,占40.9%.(2)MD组的年龄、体质量指数(BMI)、吸烟指数、收缩压、舒张压、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)及24 h尿微量白蛋白(24 hUmAlb)均高于非MD组(均P＜0.05),而MD组的胰岛素敏感性指数(ISI)则低于非MD组(P＜0.05).(3)Pearson相关分析提示MD与年龄、BMI、吸烟、收缩压、舒张压、LDL-Ch、CRP及24 hUmAlb呈正相关.结论初诊T2DM患者合并MD与多种因素相关,须及早控制各种危险因素,以防止MD的发生、发展.
목적 탐토초진2형당뇨병(T2DM)환자대혈관병변(MD)적상관위험인소.방법 장부합조건적232례초진T2DM환자근거유무MD분위량조:MD조여비MD조,대량조환자적다항림상지표진행비교급상관분석.결과 (1)232례환자중,합병MD자95례,점40.9%.(2)MD조적년령、체질량지수(BMI)、흡연지수、수축압、서장압、총담고순(TC)、저밀도지단백담고순(LDL-C)、C반응단백(CRP)급24 h뇨미량백단백(24 hUmAlb)균고우비MD조(균P＜0.05),이MD조적이도소민감성지수(ISI)칙저우비MD조(P＜0.05).(3)Pearson상관분석제시MD여년령、BMI、흡연、수축압、서장압、LDL-Ch、CRP급24 hUmAlb정정상관.결론 초진T2DM환자합병MD여다충인소상관,수급조공제각충위험인소,이방지MD적발생、발전.
Objective To investigate the risk factors associated with macrovascular disease in patients with newly-diagnosed type 2 diabetes. Methods According to arterial intima-media thickness(IMT)measured by color duplex ultrasonography,232 cases of newly-diagnosed type 2 diabetic patients were divided into two groups:one group were 95 cases with macrovascular disease(MD),and the other group were 137 cases without macrovascular disease (non-MD).Then various clinical data between the two groups were compared and the correlated risk factors for macrovascular disease were analyzed. Results (1)95 patients(40.9%)showed macrovascular disease in 232 patients.(2)Age,BMI,SI,systolic blood pressure,diastolic blood pressure,TC,LDL-C,CRP and 24h UmAlb were significantly higher in MD group compared with those in non-MD group(all P＜0.05);But ISI was significantly lower in MD group compared with that in non-MD group(P＜0.05).(3)Pearson correlation analysis showed that risk factors were old age,BMI,smoking,higher systolic blood pressure,higher diastolic blood pressure,TC,LDL-C,CRP and microalbuminuria. Conclusion Macrovascular disease was related to many factors.It was important to control some risk factors earlier for preventing the happening and progress of macrovascular disease.